Results 201 to 210 of about 986,127 (286)

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

open access: yesInterdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao   +10 more
wiley   +1 more source

Multiobjective Simulation–Optimization of Crop Allocation and Water Resources in Canal Command Areas Using Genetic Algorithms

open access: yesIrrigation and Drainage, EarlyView.
ABSTRACT This study develops an integrated simulation–optimization framework for sustainable crop allocation and water resource management in the Bargarh Canal Command (BCC), eastern India. Efficient irrigation allocation remains a critical challenge due to competing demands, groundwater–surface water interactions and environmental constraints ...
Priyanka Mohapatra   +2 more
wiley   +1 more source

Nanoplastics: Methods, Exposure and Effects on Domestic, Farm and Wild Animals

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Nanoplastics (NPs) are synthetic polymer particles ranging in size from 1 nm to 1 μm that have been identified as a major concern for ecosystems and organisms due to their plethora of negative effects. The aim of this review is to provide a comprehensive overview of the knowledge relating to exposure and effects of NPs in domestic (i.e., farm ...
B. De Felice   +8 more
wiley   +1 more source

Biochemical testing and pathology reveal rare cause of pediatric acute liver failure: Hyperornithinemia‐hyperammonemia‐homocitrullinuria syndrome

open access: yesJPGN Reports, EarlyView.
Abstract Hyperornithinemia‐hyperammonemia‐homocitrullinuria (HHH) syndrome is a rare metabolic condition that can cause lethargy, ataxia, tachypnea, nausea, vomiting, seizures, coma, and acute liver failure. We present a 26‐month‐old female with acute liver failure who was diagnosed with HHH 1 week after admission. Histology revealed an acute hepatitic
Tierra L. Mosher   +6 more
wiley   +1 more source

Adapted Mindfulness Training for Interoception and Adherence to the DASH Diet: A Phase 2 Randomized Clinical Trial.

open access: yesJAMA Netw Open, 2023
Loucks EB   +7 more
europepmc   +1 more source

Dental enamel hypoplasia and intra‐tooth isotope records as indicators of physiological stress and environmental variability in Early Pleistocene hippopotamids from Melka Kunture (Upper Awash, Ethiopia)

open access: yesJournal of Quaternary Science, EarlyView.
ABSTRACT Enamel hypoplasia results from temporary disruptions of enamel deposition during tooth development. It is widely used as an indicator of physiological stress in archeological and paleontological contexts; yet, its relationship with environmental conditions during tooth formation remains poorly constrained.
Giuseppe Briatico   +3 more
wiley   +1 more source

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