Results 211 to 220 of about 1,151,268 (285)

A Multimodal Deep Learning Framework Integrating Tumor Microenvironment Niches for Overall Survival Prediction in Esophageal Squamous Cell Carcinoma

iMetaMed, EarlyView.
The training cohort (n = 273) and internal validation cohort (n = 63) were obtained from Qilu Hospital of Shandong University, while the external validation cohort (n = 114) was derived from Liaoning Cancer Hospital. Multimodal input data included CT images with corresponding tumor segmentation masks, whole‐slide pathology images (WSIs), clinical data,
Yuanyue Zhang, Xiaoyan Li, Henan Zhang, Guang Yang, Chulong Zhang, Xiaomin Ni, Xuefei Lin, Huahui Li, Yan Min, Wei Teng, Yaoqin Xie, Hui Yang, Yang Zhang, Xin Hong, Md Tauhidul Islam, Shunsuke Koga, Zhihao Xie, Ping Zhou, Jingdong Zhang, Hao Yu, Xiaokun Liang, Jianbo Wang   +21 more
wiley   +1 more source

The impact of DASH diet and concurrent training on cardiometabolic risk factors and gut microbiota in individuals with ischemic heart disease: a study protocol for a randomized controlled trial. [PDF]

Trials
Pourfard NR, Dehkordi KJ, Sadeghi M, Taghian F, Shirvani E.   +4 more
europepmc   +1 more source

Gut microbiome seasonality is associated with dietary plasticity and coexistence in three sympatric Pamir ungulates

iMetaOmics, EarlyView.
This graphical abstract outlines a multi‐omics framework investigating the seasonal dietary composition and gut microbial communities of three coexisting ungulate species inhabiting the extreme high‐altitude Pamir Plateau (Ovis ammon polii, Capra sibirica, and Pseudois nayaur). By integrating dietary DNA metabarcoding, 16S rRNA gene sequencing, shotgun
Dilala Tuoliu, Lijiao Zhang, Muyang Wang, Wenxuan Xu, Kathreen Ruckstuhl, António Alves da Silva, Joana Alves, Hongchen Jiang, Weikang Yang   +8 more
wiley   +1 more source

Effect of the Modified Dietary Approach to Stop Hypertension (DASH) Diet on Glycemic Control and Insulin Resistance in Patients With Diabetes. [PDF]

Cureus
Swami S, Ghotekar LH, Prakash A, Aggarwal R, Margekar S, Gogoi P, Ojha A.   +6 more
europepmc   +1 more source

Putative trait‐based retention of oral‐derived microbes along the oral–gut axis in bamboo‐eating pandas

iMetaOmics, EarlyView.
Compared with the two herbivorous comparison species, pandas showed higher estimated oral‐source contributions and enrichment of microbial traits associated with facultative anaerobiosis, biofilm formation, and stress tolerance. These patterns are consistent with a model in which greater oral microbial input and putative host filtering may jointly ...
Lu Huang, Xiaoci Fan, Xinyue Tian, Yiying Wu, Yue Liu, Wei Wei, Honglin Wu, Lifeng Zhu   +7 more
wiley   +1 more source

Benchmarking gut microbiome indices within and across populations

iMetaOmics, EarlyView.
We compared 10 widely used gut microbiome indices in 12,561 American Gut Project participants and 10 external cohorts, testing how well each distinguished people with healthy lifestyles, responded to 79 environmental factors, and associated with 14 chronic conditions. No single index performed best on all three tasks.
Yu Sun, Yuwei Tang, Jieying Ou, Xinghan Wang, Yiwen Yuan, Xi Fu, Yiqun Deng   +6 more
wiley   +1 more source

Association between adherence to Dietary Approach to Stop Hypertension (DASH) diet with sleep quality, sleep duration, inflammation, and oxidative stress among Iranian adults. [PDF]

J Transl Med
Foroughi E, Moradmand Z, Rashki A, Shahdadian F, Rouhani P, Saneei P.   +5 more
europepmc   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

DASH Diet Adherence and Cardiovascular-Kidney Metabolic Syndrome Stages: National Health and Nutrition Examination Survey 2011-2020. [PDF]

JACC Adv
Akubo C, Washington IE, Song S, Kramer-Johansen M, Rodriguez C, Olusola-Bello M, Gledhill S, Sullivan V, Commodore-Mensah Y, Ogungbe O.   +9 more
europepmc   +1 more source

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source