Results 1 to 10 of about 432,965 (141)

Electrophysiological and Behavioral Markers of Hyperdopaminergia in DAT-KO Rats [PDF]

Biomedicines
Background/Objectives: Dopamine dysfunction (DA) is a hallmark of many neurological disorders. In this case, the mechanism of changes in dopamine transmission on behavior remains unclear.
Zoia Fesenko, Maria Ptukha, Marcelo M. da Silva, Raquel S. Marques de Carvalho, Vassiliy Tsytsarev, Raul R. Gainetdinov, Jean Faber, Anna B. Volnova   +7 more
doaj   +7 more sources

Comparative analysis of the influence of a high-fat/high-carbohydrate diet on the level of anxiety and neuromotor and cognitive functions in Wistar and DAT-KO rats. [PDF]

Physiol Rep, 2019
We compared anxiety, neuromotor, and cognitive functions in mutant rats with different allelic variants of dopamine transporter DAT knockout receiving balanced or excess in fat and fructose diet. The experiments were performed in DAT-/- homozygotes, DAT+/- heterozygotes, and DAT+/+ wild type rats.
Apryatin SA, Shipelin VA, Trusov NV, Mzhelskaya KV, Evstratova VS, Kirbaeva NV, Soto JS, Fesenko ZS, Gainetdinov RR, Gmoshinski IV.   +9 more
europepmc   +6 more sources

DOPAMINE-DEFICIENT DAT-KO RATS (DDD RATS) AS A PERSPECTIVE MODEL OF CHRONIC HYPODOPAMINERGIC STATE [PDF]

IBRO Neuroscience Reports, 2023
Zoia Fesenko, Maria Ptukha, Mikael Mor, Evgeniya Efimova, Anna Volnova   +4 more
doaj   +4 more sources

Antioxidant system alterations and physiological characteristics of neonatal and juvenile DAT‐KO rats [PDF]

Journal of Neuroscience Research, 2023
Abstract Dopamine transporter knockout (DAT‐KO) rats represent a valuable rodent model for studying the molecular and phenotypical outcomes of the effects of excessive dopamine accumulation in the synaptic cleft and the prolonged action of dopamine on neurons. Animals with DAT deficiency are characterized by hyperactivity, stereotypy,
S. A. Apryatin, D. S. Traktirov, M. N. Karpenko, I. S. Ivleva, N. S. Pestereva, M. V. Bolshakova, A. N. Trofimov, Z. S. Fesenko, V. M. Klimenko   +8 more
semanticscholar   +4 more sources

Dopamine Dysregulation and Altered Responses to Drugs Affecting Dopaminergic Transmission in a New Dopamine Transporter Knockout (DAT-KO) Rat Model

SSRN Electronic Journal, 2021
Under normal conditions, dopamine (DA) clearance after release largely depends on uptake by the DA transporter (DAT). DAT expression/activity is reduced in some neuropsychiatric and neurological disorders. Our aim was to characterize the behavioral, neurochemical and electrophysiological effects of eliminating DAT in a novel knockout rat model we ...
Jordan T, Lloyd, Andrew G, Yee, Prasanna K, Kalligappa, Anower, Jabed, Pang Y, Cheung, Kathryn L, Todd, Rashika N, Karunasinghe, Srdjan M, Vlajkovic, Peter S, Freestone, Janusz, Lipski   +9 more
semanticscholar   +6 more sources

Alterations in the expression of dopamine catabolism genes in DAT-KO rats with induced valproate syndrome

Medical academic journal
BACKGROUND: Autism spectrum disorder and attention deficit hyperactivity disorder are complex disorders of nervous development. Both diseases are diagnosed in childhood and are often comorbital. Rats with a knockout of the dopamine transporter gene (DAT) exhibit symptoms characteristic of attention deficit hyperactivity disorder.
Ilya R. Nazarov, Daria A. Obukhova, Valentina M. Kudrinskaya, Nina S. Pestereva   +3 more
semanticscholar   +4 more sources

ИММУНОГИСТОХИМИЧЕСКОЕ ИССЛЕДОВАНИЕ CART-ПЕПТИДА В МИНДАЛЕВИДНОМ ТЕЛЕ МОЗГА КРЫС ЛИНИИ DAT-KO [PDF]

Современная нейробиология: фундаментальные исследования и практические аспекты, 2022
Зухра Хисматуллина, Индира Садртдинова   +1 more
semanticscholar   +3 more sources

DOPAMINE METABOLISM IN DAT-KO RATS

NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY, 2022
Nina Pestereva, Dmitriy Traktirov, Valeria Artyomova, Zoya Fesenko, Ilya Nazarov, Marina Karpenko   +5 more
semanticscholar   +3 more sources

Comparison of tyrosine hydroxylase blocking influence on the motor function in NET-KO mice and DAT-KO mice

Journal of the Neurological Sciences, 2023
Zoia Fesenko, Evgeniya Efimova, Tatiana Sotnikova, Raul Gainetdinov   +3 more
semanticscholar   +3 more sources

EFFECTS OF ENCHANCED DOPAMIN LEVEL ON SPATIAL LONG-TERM MEMORY IN THE DAT-KO RAT

Neuroscience for Medicine and Psychology, 2019
Natalia Kurzina, Irina Aristova, Anna Volnona, Raul Gainetdinov   +3 more
semanticscholar   +3 more sources