Results 11 to 20 of about 432,984 (160)

Characterization of Behavioral Phenotypes in Heterozygous DAT Rat Based on Pedigree

Biomedicines, 2023
Dopamine is an essential neurotransmitter whose key roles include movement control, pleasure and reward, attentional and cognitive skills, and regulation of the sleep/wake cycle. Reuptake is carried out by the dopamine transporter (DAT; DAT1 SLC6A3 gene).
Gioia Zanfino, Concetto Puzzo, Vincenzo de Laurenzi, Walter Adriani   +3 more
doaj   +2 more sources

Stable Dopamine-Signaling mRNA Co-Expression in the Substantia Nigra Is Deregulated in Pathological Conditions, but Not in Dopamine Transporter Knockout Rats [PDF]

Biomolecules
Dopamine transporter (DAT) mutations are associated with neurological and psychiatric diseases, and DAT gene knockout in rats (DAT-KO) provides an opportunity to evaluate the DAT role in pathological conditions.
Anastasia N. Vaganova, Zoia S. Fesenko, Anna B. Volnova, Raul R. Gainetdinov   +3 more
doaj   +2 more sources

Chemogenetic tools for modulation of spatial learning in dopamine transporter deficient rats [PDF]

Frontiers in Neuroscience
ObjectivesWe used the chemogenetic tools for the activation of norepinephrine (NE) release in the prefrontal cortex (PFC) of dopamine transporter knockout (DAT-KO) rats. The objective of this study was to evaluate the effect of chemogenetic activation of
Arina A. Gromova, Arina A. Gromova, Taisiia S. Shemiakova, Mikhail G. Khotin, Evgeniia N. Petrunina, Anastasia D. Belskaya, Raul R. Gainetdinov, Raul R. Gainetdinov, Natalia P. Kurzina, Anna B. Volnova, Anna B. Volnova   +10 more
doaj   +2 more sources

Altered Sexual Behavior in Dopamine Transporter (DAT) Knockout Male Rats: A Behavioral, Neurochemical and Intracerebral Microdialysis Study

Frontiers in Behavioral Neuroscience, 2020
Central dopamine plays a key role in sexual behavior. Recently, a Dopamine Transporter knockout (DAT KO) rat has been developed, which displays several behavioral dysfunctions that have been related to increased extracellular dopamine levels and altered ...
Fabrizio Sanna, Jessica Bratzu, Maria Pina Serra, Damiana Leo, Marina Quartu, Marianna Boi, Stefano Espinoza, Raul R. Gainetdinov, Maria Rosaria Melis, Antonio Argiolas, Antonio Argiolas   +10 more
doaj   +2 more sources

Behavioral Phenotype in Heterozygous DAT Rats: Transgenerational Transmission of Maternal Impact and the Role of Genetic Asset

Brain Sciences, 2022
Dopamine transporter (DAT) is involved in dopamine (DA) reuptake in presynaptic terminals. Deletion of DAT results in a hyperdopaminergic KO-rat phenotype.
Greta Manoni, Concetto Puzzo, Antonella Gigantesco, Walter Adriani   +3 more
doaj   +2 more sources

Transgenerational Epigenetic Inheritance of Early-Life Stress from Grand-Dams Through Paternal Gametes: Impaired Social Cognition and Reduced Reactivity to Aversive Predictors in DAT-HET Rats [PDF]

Biology
Transgenerational epigenetic inheritance has emerged as a compelling mechanism by which early-life stress can shape behavior in descendants with no direct exposure to trauma.
Eleonora D’Antonio, Gioia Zanfino, Concetto Puzzo, Micaela Capobianco, Francesco Mannella, Vincenzo De Laurenzi, Giuseppe Curcio, Walter Adriani   +7 more
doaj   +2 more sources

Altered Co-Expression Patterns of Mitochondrial NADH-Dehydrogenase Genes in the Prefrontal Cortex of Rodent ADHD Models. [PDF]

Int J Mol Sci
Altered mitochondrial function is implicated in disorders characterized by prefrontal cortex activation deficits, including attention deficit hyperactivity disorder (ADHD).
Sylko PA, Gromova AA, Fesenko ZS, Kanov EV, Volnova AB, Gainetdinov RR, Vaganova AN.   +6 more
europepmc   +2 more sources

Social Interactions of Dat-Het Epi-Genotypes Differing for Maternal Origins: The Development of a New Preclinical Model of Socio-Sexual Apathy

Biomedicines, 2021
Social interaction is essential for life but is impaired in many psychiatric disorders. We presently focus on rats with a truncated allele for dopamine transporter (DAT).
Anna Brancato, Sara L. M. Lo Russo, Anna Sara Liberati, Cristiana Carbone, Silvia Zelli, Giovanni Laviola, Carla Cannizzaro, Walter Adriani   +7 more
doaj   +2 more sources

Rats Lacking the Dopamine Transporter Display Inflexibility in Innate and Learned Behavior [PDF]

Biomedicines
Playing a key role in the organization of striatal motor output, the dopamine (DA)-ergic system regulates both innate and complex learned behaviors.
Anastasia Belskaya, Natalia Kurzina, Artem Savchenko, Ilya Sukhanov, Arina Gromova, Raul R. Gainetdinov, Anna Volnova   +6 more
doaj   +2 more sources

Experiment 3: The effects of the 5-HT antagonist SB 224289 on locomotor activity in DAT KO and WT mice.

, 2015
Scott Hall Frank, Ichiro Sora, René Hen, Robert George   +3 more
openalex   +3 more sources