Results 31 to 40 of about 432,984 (160)

A New Paradigm for Training Hyperactive Dopamine Transporter Knockout Rats: Influence of Novel Stimuli on Object Recognition

Frontiers in Behavioral Neuroscience, 2021
Attention deficit hyperactivity disorder (ADHD) is believed to be connected with a high level of hyperactivity caused by alterations of the control of dopaminergic transmission in the brain.
Natalia P. Kurzina, Anna B. Volnova, Anna B. Volnova, Irina Y. Aristova, Raul R. Gainetdinov, Raul R. Gainetdinov   +5 more
doaj   +1 more source

Activation of the spinal and brainstem locomotor networks during free treadmill stepping in rats lacking dopamine transporter

Frontiers in Molecular Neuroscience, 2023
Dopamine is extremely important for the multiple functions of the brain and spinal cord including locomotor behavior. Extracellular dopamine levels are controlled by the membrane dopamine transporter (DAT), and animals lacking DAT (DAT-KO) are ...
Aleksandr Veshchitskii, Polina Shkorbatova, Aleksandr Mikhalkin, Zoja Fesenko, Evgeniya V. Efimova, Raul R. Gainetdinov, Raul R. Gainetdinov, Natalia Merkulyeva   +7 more
doaj   +1 more source

Alterations in Serotonin Neurotransmission in Hyperdopaminergic Rats Lacking the Dopamine Transporter

Biomedicines, 2023
Biogenic amines dopamine (DA) and serotonin (5-HT) are among the most significant monoaminergic neurotransmitters in the central nervous system (CNS). Separately, the physiological roles of DA and 5-HT have been studied in detail, and progress has been ...
Dmitrii S. Traktirov, Ilya R. Nazarov, Valeria S. Artemova, Raul R. Gainetdinov, Nina S. Pestereva, Marina N. Karpenko   +5 more
doaj   +1 more source

Noradrenergic Modulation of Learned and Innate Behaviors in Dopamine Transporter Knockout Rats by Guanfacine

Biomedicines, 2023
Investigation of the precise mechanisms of attention deficit and hyperactivity disorder (ADHD) and other dopamine-associated conditions is crucial for the development of new treatment approaches.
Anna Volnova, Natalia Kurzina, Anastasia Belskaya, Arina Gromova, Arseniy Pelevin, Maria Ptukha, Zoia Fesenko, Alla Ignashchenkova, Raul R. Gainetdinov   +8 more
doaj   +1 more source

Modulation of Spatial Memory Deficit and Hyperactivity in Dopamine Transporter Knockout Rats via α2A-Adrenoceptors

Frontiers in Psychiatry, 2022
Attention deficit hyperactivity disorder (ADHD) is manifested by a specific set of behavioral deficits such as hyperactivity, impulsivity, and inattention.
Natalia Kurzina, Anastasia Belskaya, Arina Gromova, Alla Ignashchenkova, Raul R. Gainetdinov, Raul R. Gainetdinov, Anna Volnova, Anna Volnova   +7 more
doaj   +1 more source

A role for cortical dopamine in the paradoxical calming effects of psychostimulants

Scientific Reports, 2022
Psychostimulants have a paradoxical calming effect in the treatment of attention deficit hyperactivity disorder (ADHD), but their mechanism of action is unclear.
Sharonda S. Harris, Sara M. Green, Mayank Kumar, Nikhil M. Urs   +3 more
doaj   +1 more source

Progressive Axonal Degeneration of Nigrostriatal Dopaminergic Neurons in Calcium-Independent Phospholipase A2β Knockout Mice. [PDF]

PLoS ONE, 2016
Calcium-independent phospholipase A2β (iPLA2β, PLA2G6) is essential for the remodeling of membrane glycerophospholipids. Mutations in this gene are responsible for autosomal recessive, young onset, L-dopa-responsive parkinsonism (PARK14), suggesting a ...
Goichi Beck, Koei Shinzawa, Hideki Hayakawa, Kousuke Baba, Hisae Sumi-Akamaru, Yoshihide Tsujimoto, Hideki Mochizuki   +6 more
doaj   +1 more source

Dopamine Transporter Knockout Rats Show Impaired Wellbeing in a Multimodal Severity Assessment Approach

Frontiers in Behavioral Neuroscience, 2022
In preclinical psychiatry research, animals are central to modeling and understanding biological mechanisms of behavior and psychiatric disorders. We here present the first multimodal severity assessment of a genetically modified rat strain used in ...
Anne Stephanie Mallien, Laura Becker, Natascha Pfeiffer, Federica Terraneo, Federica Terraneo, Melissa Hahn, Anthonieke Middelman, Rupert Palme, Kerstin Camile Creutzberg, Veronica Begni, Marco Andrea Riva, Damiana Leo, Heidrun Potschka, Fabio Fumagalli, Judith R. Homberg, Peter Gass   +15 more
doaj   +1 more source

Behavioral Phenotyping of Dopamine Transporter Knockout Rats: Compulsive Traits, Motor Stereotypies, and Anhedonia

Frontiers in Psychiatry, 2018
Alterations in dopamine neurotransmission are generally associated with diseases such as attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD).
Stefano Cinque, Stefano Cinque, Francesca Zoratto, Anna Poleggi, Damiana Leo, Luca Cerniglia, Silvia Cimino, Renata Tambelli, Enrico Alleva, Raul R. Gainetdinov, Raul R. Gainetdinov, Giovanni Laviola, Walter Adriani, Walter Adriani   +13 more
doaj   +1 more source

Dopamine Transporter Knockout Rats Display Epigenetic Alterations in Response to Cocaine Exposure

Biomolecules, 2023
(1) Background: There is an urgent need for effective treatments for cocaine use disorder (CUD), and new pharmacological approaches targeting epigenetic mechanisms appear to be promising options for the treatment of this disease.
Samara Vilca, Claes Wahlestedt, Sari Izenwasser, Raul R. Gainetdinov, Marta Pardo   +4 more
doaj   +1 more source