Results 41 to 50 of about 432,984 (160)

Dopamine transporter knockout rats as the new preclinical model of hyper- and hypo-dopaminergic disorders

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2019
Rat line lacking the dopamine transporter (DAT-KO rats) was recently developed. Lack of DAT in these mutants manifests behaviorally as spontaneous hyperactivity and cognitive deficits.
I. Sukhanov, D. Leo, M. A. Tur, I. V. Belozertseva, A. Savchenko, R. R. Gainetdinov   +5 more
doaj   +1 more source

Altered neurocircuitry in the dopamine transporter knockout mouse brain. [PDF]

PLoS ONE, 2010
The plasma membrane transporters for the monoamine neurotransmitters dopamine, serotonin, and norepinephrine modulate the dynamics of these monoamine neurotransmitters.
Xiaowei Zhang, Elaine L Bearer, Benoit Boulat, F Scott Hall, George R Uhl, Russell E Jacobs   +5 more
doaj   +1 more source

The Lack of Dopamine Transporter Is Associated With Conditional Associative Learning Impairments and Striatal Proteomic Changes

Frontiers in Psychiatry, 2022
Dopamine (DA) is critically involved in different functions of the central nervous system (CNS) including control of voluntary movement, affect, reward, sleep, and cognition.
Artem Savchenko, Carina Müller, Jana Lubec, Damiana Leo, Volker Korz, Leila Afjehi-Sadat, Jovana Malikovic, Fernando J. Sialana, Gert Lubec, Ilya Sukhanov   +9 more
doaj   +1 more source

Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice.

PLoS ONE, 2012
Pregnenolone belongs to a class of endogenous neurosteroids in the central nervous system (CNS), which has been suggested to enhance cognitive functions through GABA(A) receptor signaling by its metabolites.
Peiyan Wong, Cecilia Chin Roei Chang, Christine E Marx, Marc G Caron, William C Wetsel, Xiaodong Zhang   +5 more
doaj   +1 more source

Alteration of striatal dopaminergic neurotransmission in a mouse model of DYT11 myoclonus-dystonia. [PDF]

PLoS ONE, 2012
DYT11 myoclonus-dystonia (M-D) syndrome is a neurological movement disorder characterized by myoclonic jerks and dystonic postures or movement that can be alleviated by alcohol.
Lin Zhang, Fumiaki Yokoi, Dee S Parsons, David G Standaert, Yuqing Li   +4 more
doaj   +1 more source

Inhibition of PDE10A in a New Rat Model of Severe Dopamine Depletion Suggests New Approach to Non-Dopamine Parkinson’s Disease Therapy

Biomolecules, 2022
Parkinson’s disease is the second most common neurodegenerative pathology. Due to the limitations of existing therapeutic approaches, novel anti-parkinsonian medicines with non-dopamine mechanisms of action are clearly needed.
Ilya Sukhanov, Artem Dorotenko, Zoia Fesenko, Artem Savchenko, Evgeniya V. Efimova, Mikael S. Mor, Irina V. Belozertseva, Tatyana D. Sotnikova, Raul R. Gainetdinov   +8 more
doaj   +1 more source

Elevated dopamine alters consummatory pattern generation and increases behavioral variability during learning

Frontiers in Integrative Neuroscience, 2015
The role of dopamine in controlling behavior remains poorly understood. In this study we examined licking behavior in an established hyperdopaminergic mouse model—dopamine transporter knockout (DAT KO) mice.
Mark A. Rossi, Henry H Yin
doaj   +1 more source

Persistent hyperdopaminergia decreases the peak frequency of hippocampal theta oscillations during quiet waking and REM sleep. [PDF]

PLoS ONE, 2009
Long-term changes in dopaminergic signaling are thought to underlie the pathophysiology of a number of psychiatric disorders. Several conditions are associated with cognitive deficits such as disturbances in attention processes and learning and memory ...
Kafui Dzirasa, Lucas M Santos, Sidarta Ribeiro, Jennifer Stapleton, Raul R Gainetdinov, Marc G Caron, Miguel A L Nicolelis   +6 more
doaj   +1 more source

A Custom Solution for Acoustic Startle Response Setup with Spike2-Based Data Acquisition Interface

Methods and Protocols, 2023
This article presents a low-cost and flexible software solution for acoustic startle response (ASR) test that can be used with a Spike2-based interface.
Arseniy Pelevin, Natalia Kurzina, Vladislav Zavialov, Anna Volnova   +3 more
doaj   +1 more source

Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior

Translational Psychiatry, 2021
Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc (Zn2+) also binds to the DAT, but the in vivo relevance of this interaction is unknown.
Juan L. Gomez, Jordi Bonaventura, Jacqueline Keighron, Kelsey M. Wright, Dondre L. Marable, Lionel A. Rodriguez, Sherry Lam, Meghan L. Carlton, Randall J. Ellis, Chloe J. Jordan, Guo-hua Bi, Oscar Solis, Marco Pignatelli, Michael J. Bannon, Zheng-Xiong Xi, Gianluigi Tanda, Michael Michaelides   +16 more
doaj   +1 more source