Results 51 to 60 of about 432,984 (160)

Alteration of Postural Reactions in Rats with Different Levels of Dopamine Depletion

Biomedicines, 2023
Dopamine (DA) is the critical neurotransmitter involved in the unconscious control of muscle tone and body posture. We evaluated the general motor capacities and muscle responses to postural disturbance in three conditions: normal DA level (wild-type ...
Daria S. Kalinina, Vsevolod A. Lyakhovetskii, Oleg V. Gorskii, Polina Yu. Shkorbatova, Natalia V. Pavlova, Elena Yu. Bazhenova, Yurii I. Sysoev, Raul R. Gainetdinov, Pavel E. Musienko   +8 more
doaj   +1 more source

A new “sudden fright paradigm” to explore the role of (epi)genetic modulations of the DAT gene in fear‐induced avoidance behavior

Genes, Brain and Behavior, 2020
Alterations in dopamine (DA) reuptake are involved in several psychiatric disorders whose symptoms can be investigated in knock out rats for the DA transporter (DAT‐KO).
Silvia Zelli, A. Brancato, F. Mattioli, Martina Pepe, E. Alleva, Cristiana Carbone, C. Cannizzaro, W. Adriani   +7 more
semanticscholar   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Rats Lacking Dopamine Transporter Display Increased Vulnerability and Aberrant Autonomic Response to Acute Stress

Biomolecules, 2020
The activity of the hypothalamus–pituitary–adrenal (HPA) axis is pivotal in homeostasis and presides the adaptative response to stress. Dopamine Transporter (DAT) plays a key role in the regulation of the HPA axis. We used young adult female DAT Knockout
Placido Illiano, Gregory E. Bigford, Raul R. Gainetdinov, Marta Pardo   +3 more
doaj   +1 more source

A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time

Advanced Science, EarlyView.
This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li, Qiang Ning, Zhen Li, Qian Zhang, Peilu Zhu, Jimin Zhan, Yunfu Li, Zhen Li, Liang Dong, Qing Xiong, Jiahao Liao, Jie Liu, David Jackson, Munenori Kitagawa, Zuxin Zhang, Lei Liu   +15 more
wiley   +1 more source

Redox‐aktivierte Sonden für Hochkontrastige Live‐Bildgebung Postsynaptischer Neuronaler Gerüste

Angewandte Chemie, EarlyView.
Sylives sind modifizierte fluoreszierende Peptide für eine kontrastreiche Live‐Bildgebung inhibitorischer (Gephyrin) und exzitatorischer (PSD‐95) postsynaptischer Gerüststrukturen in nativen Neuronen. Eine saubere Markierung erfordert niedrige Sondenkonzentrationen im Nanomolarbereich, während die Aufnahme mikromolare Konzentrationen zellpenetrierender
Christiane Huhn, Clémence Mille, Sheng‐Yang Ho, Felix Lützenkirchen, Vladimir Khayenko, Melanie Hein, Christian Werner, Matthias Kneussel, Johannes W. Hell, Christian G. Specht, Hans M. Maric   +10 more
wiley   +1 more source

Kombinierte lösungs‐ und oberflächengestützte Synthese eines vollständig kondensierten, kreuzförmigen Phthalocyanin‐Pentamers

Angewandte Chemie, EarlyView.
Ein Phthalocyanin‐(Pc)‐Pentamer wurde durch die Kombination lösung‐ und oberflächengestützter Synthese unter Ultrahochvakuumbedingungen erhalten. Die entstandene Pc‐basierte Nanostruktur weist ein exaktes stöchiometrisches Verhältnis von 4:1 zweier unterschiedlicher Metallionen auf, mit präziser Positionskontrolle.
Luis M. Mateo, Tzu‐Chao Hung, Andreas Rank, Raffael Spachtholz, Felix Giselbrecht, Jonas Schön, Leo Gross, Jascha Repp, Diego Peña   +8 more
wiley   +1 more source

Phasentrennung von Nukleinsäuren: Mechanismen, Eigenschaften und Anwendungen

Angewandte Chemie, EarlyView.
Jüngste Entdeckungen zeigen, dass einzelsträngige langkettige Nukleinsäuren temperaturinduziert phasentrennen und dabei mikrometergroße Kondensate bilden. Dieser Minireview fasst das aktuelle mechanistische Verständnis dieses Phänomens zusammen, beschreibt Strategien zur gezielten Kontrolle der physikalischen und chemischen Eigenschaften der Kondensate
Weixiang Chen, Johann Fritzen, Andreas Walther   +2 more
wiley   +1 more source

Experiences of disrespect and abuse during childbirth in the World Health Organization European region: A mixed‐method study among 22 countries

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Despite advancements in maternity quality care worldwide, mistreatment of women during childbirth persists. Currently, there is a gap of knowledge on the occurrence of disrespect and abuse during childbirth in the World Health Organization (WHO) European region.
Anna Galle, Helga Berghman, Ilaria Mariani, Maria Verdecchia, Arianna Bomben, Eline Skirnisdottir Vik, Daniela Drandic, Elizabete Pumpure, Raquel Costa, Helen Elden, Céline Miani, Barbara Baranowska, Antigoni Sarantaki, Zalka Drglin, Jelena Radetic, Alina Liepinaitienė, Virginie Rozée, Alessia Abderhalden‐Zellweger, Amira Cerimagic, Martina König‐Bachmann, Ourania Kolokotroni, Ilana Chertok, Maryse Arendt, Stefano delle Vedove, Ingvild Hersoug Nedberg, Magdalena Kurbanovic, Gunta Lazdane, Tiago Miguel Pinto, Karolina Linden, Stephanie Batram‐Zantvoort, Urszula Tataj‐Puzyna, Dimitra Metallinou, Anja Bohinec, Jovana Ružičić, Marija Mizgaitienė, Elise de La Rochebrochard, Michael Gemperle, Imola Simon, Maria Karanikola, Barbara Tasch, Simona Fumagalli, Marzia Lazzerini, on behalf of the IMagiNE EURO study group, Martina König‐Bachmann, Christoph Zenzmaier, Simon Imola, Elisabeth D’Costa, Anna Galle, Silke D’Hauwers, Amira Ćerimagić, Ourania Kolokotroni, Eleni Hadjigeorgiou, Maria Karanikola, Nicos Middleton, Ioli Orphanide Eteocleous, Daniela Drandić, Magdalena Kurbanović, Lenka Laubrova Zirovnicka, Miloslava Kramná, Rozée Virginie, Elise de La Rochebrochard, Kristina Löfgren, Céline Miani, Stephanie Batram‐Zantvoort, Antigoni Sarantaki, Dimitra Metallinou, Aikaterini Lykeridou, Ilana Chertok, Rada Artzi‐Medvedik, Marzia Lazzerini, Emanuelle Pessa Valente, Ilaria Mariani, Arianna Bomben, Stefano Delle Vedove, Sandra Morano, Antonella Nespoli, Simona Fumagalli, Elizabete Pumpure, Dace Rezeberga, Dārta Jakovicka, Gita Jansone‐Šantare, Anna Šibalova, Elīna Voitehoviča, Dārta Krēsliņa, Alina Liepinaitienė, želika Kondrakova, Marija Mizgaitienė, Simona Juciūtė, Maryse Arendt, Barbara Tasch, Enrico Lopriore, Thomas Van den Akker, Ingvild Hersoug Nedberg, Sigrun Kongslien, Eline Skirnisdottir Vik, Barbara Baranowska, Urszula Tataj‐Puzyna, Beata Szlendak, Paulina Pawlicka, Raquel Costa, Catarina Barata, Teresa Santos, Heloísa Dias, Tiago Miguel Pinto, Sofia Marques, Ana Meireles, Joana Oliveira, Mariana Pereira, Maria Arminda Nunes, Marina Ruxandra Otelea, Jelena Radetić, Jovana Ružičić, Zalka Drglin, Anja Bohinec, Serena Brigidi, Alejandra Oliden, Lara Martín Castañeda, Helen Elden, Karolina Linden, Mehreen Zaigham, Claire de Labrusse, Alessia Abderhalden‐Zellweger, Anouck Pfund, Harriet Thorn, Susanne Grylka, Michael Gemperle, Antonia Mueller   +126 more
wiley   +1 more source

Genetic loss of the dopamine transporter significantly impacts behavioral and molecular responses to sub-chronic stress in mice

Frontiers in Molecular Neuroscience
Dopaminergic neurotransmission has emerged as a critical determinant of stress susceptibility and resilience. Although the dopamine transporter (DAT) is known to play a key role in maintaining dopamine (DA) homeostasis, its importance for the regulation ...
Avelina Petri, Abigail Sullivan, Kristen Allen, Benjamin D. Sachs   +3 more
doaj   +1 more source