Results 171 to 180 of about 3,746 (200)

The role of DAT1 gene on the rapid detection of task novelty

Neuropsychologia, 2010
In an environment with a myriad of different stimuli, the fast detection of novel and behaviorally relevant signals becomes crucial for an adaptive behavior. The detection of task-novelty has been related to striatum-prefrontal cortex (PFC) pathways involving dopaminergic (DA) neurotransmission.
Garcia-Garcia M, Barceló F, Clemente IC, Escera C   +3 more
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The Relation of the Dopamine Transporter Gene (DAT1) to Symptoms of Internalizing Disorders in Children

Behavior Genetics, 1998
The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders, Tourette's disorder, and obsessive-compulsive disorder was examined using both within- and between-family tests of association. The sample consisted of clinic-referred children and their siblings and controls and their siblings.
Stephanie L Sherman, Irwin D Waldman, David C. Rowe   +2 more
exaly   +3 more sources

Association of the Dopamine Transporter Gene (DAT1) With Poor Methylphenidate Response

Journal of the American Academy of Child & Adolescent Psychiatry, 1999
This study attempted to relate the alleles of the D2 (DRD2), D4 (DRD4), and dopamine transporter (DAT1) genes to the behavioral outcome of methylphenidate therapy.African-American children with attention-deficit hyperactivity disorder were treated with methylphenidate in doses not in excess of 60 mg/day. The dosage was increased until behavioral change
B G, Winsberg, D E, Comings
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Population genetic study of the human dopamine transporter gene (DAT1)

Genetic Epidemiology, 1995
AbstractThe human dopamine transporter gene, DAT1, acts to transport released dopamine into presynaptic terminals of the brain. The possibility that the DAT1 gene plays a role in genetic diseases of the brain has led to studies of DAT1 in several psychiatric and neurological disorders. Previous sequence analysis of DAT1 revealed a 40‐bp repeat in the 3′
L A, Doucette-Stamm, D J, Blakely, J, Tian, S, Mockus, J I, Mao   +4 more
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DAT1 methylation changes in alcohol-dependent individuals vs. controls

Journal of Psychiatric Research, 2015
The dopaminergic system plays a crucial role in the development of alcohol dependence. Regulation of the extracellular dopamine concentration is driven by dopamine transporter. Both, the expression and function of dopamine transporter, are influenced by chronic alcohol intake.
Andrzej, Jasiewicz, Błażej, Rubiś, Jerzy, Samochowiec, Iwona, Małecka, Aleksandra, Suchanecka, Marcin, Jabłoński, Anna, Grzywacz   +6 more
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DAT1 gene polymorphism in alcoholism: a family-based association study

Biological Psychiatry, 1999
The present study tests the hypothesis that the 9-repeat allele of the dopamine transporter gene (DAT1; SLC6A3) is more frequent in alcohol-dependent probands--and in particular those with severe withdrawal symptoms (seizures and/or delirium)--compared to nonalcoholics.To avoid stratification effects, the family-based association approach of Falk and ...
P, Franke, S G, Schwab, M, Knapp, M, Gänsicke, C, Delmo, P, Zill, M, Trixler, D, Lichtermann, J, Hallmayer, D B, Wildenauer, W, Maier   +10 more
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Potential association of DRD2 and DAT1 genetic variation with heroin dependence

Neuroscience Letters, 2009
The aim of our study was to investigate the potential association of dopamine receptor D2 gene (DRD2) TaqI RFLP A (rs1800497) and dopamine transporter gene (DAT) 3'untranslated region VNTR genetic variations with heroin addiction. Genotyping was performed using PCR-based techniques in 530 heroin abusers and 500 controls.
Qiao-Fang, Hou, Sheng-Bin, Li
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No association between the DAT1 10‐repeat allele and ADHD in the Iranian population

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2007
AbstractAssociation studies between attention‐deficit hyperactivity disorder (ADHD) and the 10‐repeat allele of a polymorphism (a 40 bp variable number of tandem repeats) in the dopamine transporter gene (DAT1) have resulted in mixed findings in different populations.
M M, Banoei, T, Majidizadeh, E, Shirazi, N, Moghimi, M, Ghadiri, H, Najmabadi, M, Ohadi   +6 more
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DAT1 and BDNF polymorphisms interact to predict Aβ and tau pathology

Neurobiology of Aging
Previous work has associated polymorphisms in the dopamine transporter gene (rs6347 in DAT1/SLC6A3) and brain derived neurotrophic factor gene (Val66Met in BDNF) with atrophy and memory decline. However, it is unclear whether these polymorphisms relate to atrophy and cognition through associations with Alzheimer's disease pathology.
Claire J, Ciampa, Thomas M, Morin, Alice, Murphy, Renaud La, Joie, Susan M, Landau, Anne S, Berry   +5 more
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Environmental and genetic determinants of childhood depression: The roles of DAT1 and the antenatal environment

Journal of Affective Disorders, 2016
Research on adolescent and adult populations has linked depression to variation in several monoaminergic genes, but genetic association studies on depression in children are limited. Additionally, few studies have investigated whether stressors occurring very early in development moderate the influence of certain genes on depression.
D'Souza, Stephanie, Thompson, John, Slykerman, Rebecca, Marlow, G, Wall, Clare, Murphy, Rinki, Ferguson, Lynnette, Mitchell, Edwin, Waldie, Karen   +8 more
openaire   +3 more sources