Results 171 to 180 of about 3,265 (196)

Occurrence of DAT1 (VNTR) Polymorphism in Individuals with HIV Infection

Current Pharmacogenomics and Personalized Medicine, 2021
Background: Antiretroviral treatment (ART) has been reported to make changes in the functioning of dopaminergic neurons by altering the expression of dopamine active transporter (DAT). ART containing efavirenz drug has been related to show the adverse reactions on the central nervous system (CNS).
HariOm Singh, Sonam Lata
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Association of the Dopamine Transporter Gene (DAT1) With Poor Methylphenidate Response

Journal of the American Academy of Child & Adolescent Psychiatry, 1999
This study attempted to relate the alleles of the D2 (DRD2), D4 (DRD4), and dopamine transporter (DAT1) genes to the behavioral outcome of methylphenidate therapy.African-American children with attention-deficit hyperactivity disorder were treated with methylphenidate in doses not in excess of 60 mg/day. The dosage was increased until behavioral change
B G, Winsberg, D E, Comings
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Population genetic study of the human dopamine transporter gene (DAT1)

Genetic Epidemiology, 1995
AbstractThe human dopamine transporter gene, DAT1, acts to transport released dopamine into presynaptic terminals of the brain. The possibility that the DAT1 gene plays a role in genetic diseases of the brain has led to studies of DAT1 in several psychiatric and neurological disorders. Previous sequence analysis of DAT1 revealed a 40‐bp repeat in the 3′
L A, Doucette-Stamm, D J, Blakely, J, Tian, S, Mockus, J I, Mao   +4 more
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DAT1 methylation changes in alcohol-dependent individuals vs. controls

Journal of Psychiatric Research, 2015
The dopaminergic system plays a crucial role in the development of alcohol dependence. Regulation of the extracellular dopamine concentration is driven by dopamine transporter. Both, the expression and function of dopamine transporter, are influenced by chronic alcohol intake.
Andrzej, Jasiewicz, Błażej, Rubiś, Jerzy, Samochowiec, Iwona, Małecka, Aleksandra, Suchanecka, Marcin, Jabłoński, Anna, Grzywacz   +6 more
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DAT1 gene polymorphism in alcoholism: a family-based association study

Biological Psychiatry, 1999
The present study tests the hypothesis that the 9-repeat allele of the dopamine transporter gene (DAT1; SLC6A3) is more frequent in alcohol-dependent probands--and in particular those with severe withdrawal symptoms (seizures and/or delirium)--compared to nonalcoholics.To avoid stratification effects, the family-based association approach of Falk and ...
P, Franke, S G, Schwab, M, Knapp, M, Gänsicke, C, Delmo, P, Zill, M, Trixler, D, Lichtermann, J, Hallmayer, D B, Wildenauer, W, Maier   +10 more
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Potential association of DRD2 and DAT1 genetic variation with heroin dependence

Neuroscience Letters, 2009
The aim of our study was to investigate the potential association of dopamine receptor D2 gene (DRD2) TaqI RFLP A (rs1800497) and dopamine transporter gene (DAT) 3'untranslated region VNTR genetic variations with heroin addiction. Genotyping was performed using PCR-based techniques in 530 heroin abusers and 500 controls.
Qiao-Fang, Hou, Sheng-Bin, Li
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No association between the DAT1 10‐repeat allele and ADHD in the Iranian population

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2007
AbstractAssociation studies between attention‐deficit hyperactivity disorder (ADHD) and the 10‐repeat allele of a polymorphism (a 40 bp variable number of tandem repeats) in the dopamine transporter gene (DAT1) have resulted in mixed findings in different populations.
M M, Banoei, T, Majidizadeh, E, Shirazi, N, Moghimi, M, Ghadiri, H, Najmabadi, M, Ohadi   +6 more
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The Relation of the Dopamine Transporter Gene (DAT1) to Symptoms of Internalizing Disorders in Children

Behavior Genetics, 1998
The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders, Tourette's disorder, and obsessive-compulsive disorder was examined using both within- and between-family tests of association. The sample consisted of clinic-referred children and their siblings and controls and their siblings.
D C, Rowe, C, Stever, J M, Gard, H H, Cleveland, M L, Sanders, A, Abramowitz, S T, Kozol, J H, Mohr, S L, Sherman, I D, Waldman   +9 more
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Environmental and genetic determinants of childhood depression: The roles of DAT1 and the antenatal environment

Journal of Affective Disorders, 2016
Research on adolescent and adult populations has linked depression to variation in several monoaminergic genes, but genetic association studies on depression in children are limited. Additionally, few studies have investigated whether stressors occurring very early in development moderate the influence of certain genes on depression.
D'Souza, Stephanie, Thompson, John, Slykerman, Rebecca, Marlow, G, Wall, Clare, Murphy, Rinki, Ferguson, Lynnette, Mitchell, Edwin, Waldie, Karen   +8 more
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Role of dopamine transporter gene (DAT1) polymorphisms in personality traits variation

Russian Journal of Genetics, 2009
According to psychobiological model of personality proposed by Cloninger, personality traits characterizing enhanced tendency to novel stimuli, impulsivity and sociability are influenced by dopaminergic system functioning. The present study considered both the main effect of two polymorphic loci (VNTR and 2319G>A) in dopamine transporter gene (DAT1 ...
Kazantseva, AV, Khusnutdinova, EK, Gaysina, DA, Malykh, SB   +3 more
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