Results 61 to 70 of about 1,780,354 (311)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Characterisation of precursory seismic activity towards early warning of landslides via semi-supervised learning

Scientific Reports
This study demonstrates that machine learning from seismograms, obtained from commonly deployed seismometers, can identify the early stages of slope failure in the field.
David Murray, Lina Stankovic, Vladimir Stankovic, Stella Pytharouli, Adrian White, Ben Dashwood, Jonathan Chambers   +6 more
doaj   +1 more source

The effectiveness of corpus-based training on collocation use in L2 writing for Chinese senior secondary school students

Journal of China Computer-Assisted Language Learning, 2021
Corpus tools are known to be effective in helping L2 learners improve their writing, especially regarding their use of words. Most corpus-based L2 writing research has focused on university students while little attention has been paid to secondary ...
Fang Liuqin, Ma Qing, Yan Jiahao
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

PlayPhrase.Me: A multimedia corpus for foreign language education

Technology in Language Teaching & Learning
Technological advancements have not only introduced new tools for language education but also tailored apps and resources for specific language skills.
Ibrahim Halil Topal
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Learning Finite State Machine Controllers from Motion Capture Data

, 2009
With characters in computer games and interactive media increasingly being based on real actors, the individuality of an actor's performance should not only be reflected in the appearance and animation of the character but also in the Artificial ...
M. Gillies, Gillies, Marco
core   +1 more source

Data-Driven Learning and Language Pedagogy [PDF]

, 2016
Language corpora have many uses in language study, including for learners and other users of foreign languages in an approach that has come to be known as data-driven learning (DDL). This boils down to the learner's ability to find answers to their questions by using software to access large collections of authentic texts relevant to their needs, as ...
openaire   +2 more sources

Deep learned triple-tracer multiplexed PET myocardial image separation

Frontiers in Nuclear Medicine
IntroductionIn multiplexed positron emission tomography (mPET) imaging, physiological and pathological information from different radiotracers can be observed simultaneously in a single dynamic PET scan. The separation of mPET signals within a single PET
Bolin Pan, Paul K. Marsden, Andrew J. Reader   +2 more
doaj   +1 more source