Results 141 to 150 of about 58,206,617 (356)

Effects of an orexin receptor 2-selective agonist on salivary secretion in rats

Scientific Reports
Narcolepsy type 1 (NT1) is caused by a significant loss of orexin-producing neurons. In clinical trials, multiple orexin receptor 2 (OX2R)-selective agonists (e.g., danavorexton, TAK-994, and oveporexton) improved wakefulness and decreased cataplexy in ...
Jose Ichishima, Masanori Nakakariya, Haruhide Kimura   +2 more
doaj   +1 more source

Technical Analysis of Horizontal Section Geosteering

Cejing jishu
The angle between borehole trajectory and formation interface is the key parameter of horizontal section trajectory control in the geosteering process of horizontal wells.
LI Xiaoqiang, YANG Bin, YANG Zhihua
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Going concern in British New Guinea : a sound and plain proposition to investors / Angabunga River Plantations Limited. [PDF]

, 1917
Cover title.; Accompanied by : Report / by John Richmond. 7 p. : ill. ; 19 x 24 cm. 1911.; Electronic reproduction. Canberra, A.C.T. National Library of Australia, 2009.; Report by Mr.
Angabunga River Plantations Limited.
core  

Data-limited manipulations of T1 difficulty influence the attentional blink [PDF]

, 2007
When two targets are embedded in a temporal stream of distractors, second-target identification is initially impaired and then gradually improves as intertarget interval lengthens (attentional blink; AB).
Ohan, J. L., Visser, T. A., Ohan, Jeneva, Visser, Troy   +3 more
core   +1 more source

Optimizing long term disease prevention with reinforcement learning: a framework for precision lipid control

npj Digital Medicine
The prevention of chronic disease is a long-term combat with continual fine-tuning to adapt to the course of disease. Without comprehensive insights, prescriptions may prioritize short-term gains but deviate from trajectories toward long-term survival ...
Yekai Zhou, Ruibang Luo, Joseph Edgar Blais, Kathryn C. B. Tan, David Tak Wai Lui, Kai Hang Yiu, Francisco Tsz Tsun Lai, Eric Yuk Fai Wan, Ching-Lung Cheung, Ian CK Wong, Celine SL Chui   +10 more
doaj   +1 more source

An Improved Decline Curve Analysis Method via Ensemble Learning for Shale Gas Reservoirs

Energies
As a clean unconventional energy source, shale gas reservoirs are increasingly important globally. Accurate prediction methods for shale gas production capacity can bring significant economic benefits by reducing construction and operating costs. Decline
Yu Zhou, Zaixun Gu, Changyu He, Junwen Yang, Jian Xiong   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Combining empirical indicators and expert knowledge for surveillance of data-limited sea trout stocks

Ecological Indicators, 2019
Inland and diadromous fish stocks can support important ecological, social and cultural functions. However, many of these stocks are data-limited and do not have formal state assessments or management reference points.
S. Shephard, Q. Josset, I. Davidson, R. Kennedy, Katarina Magnusson, P. Gargan, A. Walker, R. Poole   +7 more
semanticscholar   +1 more source