Results 131 to 140 of about 12,309,063 (288)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Artificial intelligence and medical research databases: ethical review by data access committees. [PDF]

BMC Med Ethics, 2023
McKay F, Williams BJ, Prestwich G, Bansal D, Treanor D, Hallowell N.   +5 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A vehicle license plate data access model based on the jump hash consistency algorithm. [PDF]

PLoS One, 2023
Wang W, Cheng W, Chen J, Wang Z, Zhang Y, Yu Y.   +5 more
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

DNA storage in thermoresponsive microcapsules for repeated random multiplexed data access. [PDF]

Nat Nanotechnol, 2023
Bögels BWA, Nguyen BH, Ward D, Gascoigne L, Schrijver DP, Makri Pistikou AM, Joesaar A, Yang S, Voets IK, Mulder WJM, Phillips A, Mann S, Seelig G, Strauss K, Chen YJ, de Greef TFA.   +15 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Healthcare Utilization and Cost in the Two Years Before Neuromodulation Implantation Among Medicaid Enrollees with Drug-Resistant Epilepsy

ClinicoEconomics and Outcomes Research
Kathryn Evans,1 Qian Li,1 Lu Zhang,2 Sandi Lam,2 Bronwyn Do Rego,3 Vanessa Danielson,3 Reginald Lassagne,3 Ariel Berger1 1Thermo Fisher Scientific, Waltham, MA, USA; 2Department of Neurosurgery, Division of Pediatric Neurosurgery, Ann and Robert H. Lurie
Evans K, Li Q, Zhang L, Lam S, Do Rego B, Danielson V, Lassagne R, Berger A   +7 more
doaj  

Blockchain-Based Data Access Control and Key Agreement System in IoT Environment. [PDF]

Sensors (Basel), 2023
Lee J, Kim M, Park K, Noh S, Bisht A, Das AK, Park Y.   +6 more
europepmc   +1 more source