Results 131 to 140 of about 10,909,632 (287)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Artificial intelligence and medical research databases: ethical review by data access committees. [PDF]

BMC Med Ethics, 2023
McKay F, Williams BJ, Prestwich G, Bansal D, Treanor D, Hallowell N.   +5 more
europepmc   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

A vehicle license plate data access model based on the jump hash consistency algorithm. [PDF]

PLoS One, 2023
Wang W, Cheng W, Chen J, Wang Z, Zhang Y, Yu Y.   +5 more
europepmc   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Healthcare Utilization and Cost in the Two Years Before Neuromodulation Implantation Among Medicaid Enrollees with Drug-Resistant Epilepsy

ClinicoEconomics and Outcomes Research
Kathryn Evans,1 Qian Li,1 Lu Zhang,2 Sandi Lam,2 Bronwyn Do Rego,3 Vanessa Danielson,3 Reginald Lassagne,3 Ariel Berger1 1Thermo Fisher Scientific, Waltham, MA, USA; 2Department of Neurosurgery, Division of Pediatric Neurosurgery, Ann and Robert H. Lurie
Evans K, Li Q, Zhang L, Lam S, Do Rego B, Danielson V, Lassagne R, Berger A   +7 more
doaj  

DNA storage in thermoresponsive microcapsules for repeated random multiplexed data access. [PDF]

Nat Nanotechnol, 2023
Bögels BWA, Nguyen BH, Ward D, Gascoigne L, Schrijver DP, Makri Pistikou AM, Joesaar A, Yang S, Voets IK, Mulder WJM, Phillips A, Mann S, Seelig G, Strauss K, Chen YJ, de Greef TFA.   +15 more
europepmc   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Blockchain-Based Data Access Control and Key Agreement System in IoT Environment. [PDF]

Sensors (Basel), 2023
Lee J, Kim M, Park K, Noh S, Bisht A, Das AK, Park Y.   +6 more
europepmc   +1 more source