Results 141 to 150 of about 41,637,557 (298)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
ClinicoEconomics and Outcomes ResearchKathryn Evans,1 Qian Li,1 Lu Zhang,2 Sandi Lam,2 Bronwyn Do Rego,3 Vanessa Danielson,3 Reginald Lassagne,3 Ariel Berger1 1Thermo Fisher Scientific, Waltham, MA, USA; 2Department of Neurosurgery, Division of Pediatric Neurosurgery, Ann and Robert H. Lurie
Evans K +7 more
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
1300 Miiiii Su-eel Houston, TX 77002 713-989-2000 DAKOTA ACCESS, LLC August 31, 2015 Mr. Mike Carlson Iowa Department of Transportation Water Resources Section - Wetlands Unit 800 Lincoln Way Ames, LA 50010 Re: Dakota Access, LLC Dakota Access Pipeline ...
Dakota Access, LLC;
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
2023-10-28 - DHS Data Access - CoreTrustSeal Requirements 2017-2019
CoreTrustSeal ...
DHS Data Access
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
M3: Conversational LLMs simplify secure clinical data access, understanding, and analysis. [PDF]
PLOS Digit HealthAl Attrach R +5 more
europepmc +1 more source