Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
From data silos to actionable insights: a comparative evaluation of data access models and practical guidelines for animal health surveillance. [PDF]
Front Vet SciNoor S +10 more
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Dakota Access Pipeline Project, Dakota Access, LLC, cultural avoidance sites, 11MY227
PCN Review Area 64 f (j> '• O) ^ o 2 ' O - S9 Q - (/) o ( (/) 3 - 0) I ^ 0?5 ■: O ^ ' < CO i: i5 z o cc —1 ' ro o LLl (N "w @ O CD -p o o ^ ce: . JZ Q. : ro O : Q.
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Towards a standardised cross-sectoral data access agreement template for research: a core set of principles for data access within trusted research environments. [PDF]
Int J Popul Data Sci, 2023 Brophy R +12 more
europepmc +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Assessing social media platform data access for automated early warning of public health threats. [PDF]
Eur J Public HealthSiling K, Orchard F, Espinosa L.
europepmc +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Dakota Access Pipeline Project, Dakota Access, LLC, PCN map index, Illinois - St. Louis District
Path: R:\Projects\14\146\114027000_EnergyTransfer_DAPL_Confidential\GIS\MXD\Permit_Figures\DAPL_Permit_Figures_lndex_St_Louis_20141222.mxd Melisa.Bernard 12/22/2014 --I ^ r I XffjnTvfcf'^ ,1>'| Review Area 1 PCN Review Area 2 Lat: 39.89|^^ Long: -90.62^|
Dakota Access, LLC
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