Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Dakota Access Pipeline Project, Dakota Access, LLC, PCN map, Illinois - Rock Island District
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Dakota Access, LLC;
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Examining Data Access Gaps for Tribal Epidemiology Centers: Qualitative Interviews and a 50-State Syphilis Data Audit. [PDF]
J Public Health Manag PractConte K +6 more
europepmc +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
SynthCraft: An AI partner for synthetic data generation to support data access and augmentation in healthcare. [PDF]
PLOS Digit HealthCallender T +5 more
europepmc +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Figure A-1, Dakota Access Pipeline Project, Dakota Access, LLC, project overview
Path: R:\ETC\80879_DAPL\GIS\DataFiles\ArcDocs\BA_Maps\BA_Fall2015\A01_Pg1_BA_Overview_AIIActionAreas.mxd jdringman 11/4/2015 COPYRIGHT© 2015 BURNS & McDONNELL ENGINEERING COMPANY, INC.
Dakota Access, LLC;
core
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Establishing the Resilient Under-resourced Regions Addressing Life-threatening risk in VETeranS dataset (RURAL-VETS): building insights and critical data access for rural-residing Veterans. [PDF]
Front Public HealthHolliday R +7 more
europepmc +1 more source