Results 151 to 160 of about 41,637,557 (298)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Dakota Access Pipeline Project, Dakota Access, LLC, PCN area review, PCN number: SL66

Path: R:\ETC\80879_DAPL\GIS\DataFiles\ArcDocs\Mapbooks\PCN_SL66_20160406\DAPL_IL_StLouis_66PCN_MapComparison.mxd jdringman 4/6/2016 COPYRIGHT© 2016 BURNS & McDONNELL ENGINEERING COMPANY, INC. Service Layer Credits: -i/t' i- . A / A" / ■' ,v. ■■ ' |r ' " :
Dakota Access, LLC;
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

dbfishR: An R package for fish and water quality data access and entry. [PDF]

Data Brief
Wilson MJ, Ashcraft SA, Kirk MA, Ressler DE.   +3 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Quantifying the Tolerability of Antipsychotic Treatment-Related Side Effects in Schizophrenia: A Survey Study of Patients and Caregiver Proxies

Patient Preference and Adherence
Melissa Culhane Maravic,1 Kelly Birch,1 Anh Thy H Nguyen,1 Alicia Subasinghe,2 Elizabeth Stafford,3 Christopher Zacker2 1Precision AQ, New York, NY, USA; 2Cerevel Therapeutics, Cambridge, MA, USA; 3National Alliance on Mental Illness, Arlington, VA ...
Maravic MC, Birch K, Nguyen ATH, Subasinghe A, Stafford E, Zacker C   +5 more
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Quantifying effects of the European Health Data Space on the app ecosystem and data access. [PDF]

NPJ Digit Med
Brückner S, Riedel R, Hetmank S, Fritsch K, Freyer O, Gilbert S.   +5 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Device and Data Access Considerations for Digital Health Studies Using Consumer-Grade Wearables: An Experience-Based Tutorial. [PDF]

Clin Transl Sci
Zhu M, Spencer JD, Chesak S, Romanowicz M, Chauhan M, Dyrbye LN, Croarkin PE, Bobo WV, Athreya AP.   +8 more
europepmc   +1 more source