Results 171 to 180 of about 10,909,632 (287)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Shaping the future EHDS: recommendations for implementation of Health Data Access Bodies in the HealthData@EU infrastructure for secondary use of electronic health data. [PDF]

Eur J Public Health
Svingel LS, Jensen CE, Kjeldsen GF, Pedersen MH, Kalra D, Christiansen CF, Vad KH.   +6 more
europepmc   +1 more source

Quantum readout and gradient deep learning model for secure and sustainable data access in IWSN. [PDF]

PeerJ Comput Sci, 2022
Alzubi OA.
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Ensuring the ethical use of big data: lessons from secure data access. [PDF]

Heliyon, 2022
Wiltshire D, Alvanides S.
europepmc   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Improving transparency in data access processes: Developing best practice standards and promoting system-wide change through a competitive funding call. [PDF]

Int J Popul Data Sci
Macaulay Y, Bellavia E, Brophy R, Coulter A, Glampson B, Gilbert B, Holcroft A, Mayer E, McNamara E, O'Sullivan K, Quattroni P, Seymour D, Silove Y, Tembo D, Morris AD, Smith C, Boyd A.   +16 more
europepmc   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Implementation report on pioneering federated data access for the German National Emergency Department Data Registry. [PDF]

NPJ Digit Med
Bienzeisler J, Kombeiz A, Ehrentreich S, Otto R, Schirrmeister W, Pegoraro M, Brammen D, Puladi B, Röhrig R, W Majeed R.   +9 more
europepmc   +1 more source

Health, Pesticide Adjuvants, and Inert Ingredients: California Case Study Illustrates Need for Data Access. [PDF]

Environ Health Perspect, 2022
Cox C, Zeiss M.
europepmc   +1 more source