Results 171 to 180 of about 12,309,063 (288)

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Shaping the future EHDS: recommendations for implementation of Health Data Access Bodies in the HealthData@EU infrastructure for secondary use of electronic health data. [PDF]

Eur J Public Health
Svingel LS, Jensen CE, Kjeldsen GF, Pedersen MH, Kalra D, Christiansen CF, Vad KH.   +6 more
europepmc   +1 more source

Quantum readout and gradient deep learning model for secure and sustainable data access in IWSN. [PDF]

PeerJ Comput Sci, 2022
Alzubi OA.
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Ensuring the ethical use of big data: lessons from secure data access. [PDF]

Heliyon, 2022
Wiltshire D, Alvanides S.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Improving transparency in data access processes: Developing best practice standards and promoting system-wide change through a competitive funding call. [PDF]

Int J Popul Data Sci
Macaulay Y, Bellavia E, Brophy R, Coulter A, Glampson B, Gilbert B, Holcroft A, Mayer E, McNamara E, O'Sullivan K, Quattroni P, Seymour D, Silove Y, Tembo D, Morris AD, Smith C, Boyd A.   +16 more
europepmc   +1 more source

OME-NGFF: a next-generation file format for expanding bioimaging data-access strategies. [PDF]

Nat Methods, 2021
Moore J, Allan C, Besson S, Burel JM, Diel E, Gault D, Kozlowski K, Lindner D, Linkert M, Manz T, Moore W, Pape C, Tischer C, Swedlow JR.   +13 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Implementation report on pioneering federated data access for the German National Emergency Department Data Registry. [PDF]

NPJ Digit Med
Bienzeisler J, Kombeiz A, Ehrentreich S, Otto R, Schirrmeister W, Pegoraro M, Brammen D, Puladi B, Röhrig R, W Majeed R.   +9 more
europepmc   +1 more source