Results 61 to 70 of about 2,320,360 (265)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Accuracy Of Analytical Data

HortScience, 1988
Abstract At the 1987 International Conference on Heavy Metals in the Environment, conferees expressed concern regarding the accuracy of analytical data in the published scientific literature. Journals dealing with human health and environmental issues are now rejecting papers in which authors fail to use either accepted reference ...
openaire   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Development of a web application to evaluate spirometric curve and clinical variables to support COPD diagnosis in primary care

Biomédica: revista del Instituto Nacional de Salud
Introduction. Choric obstructive pulmonary disease (COPD) is the third mortality cause in the world, and the development of useful diagnostic tools is necessary to improve timely diagnostic rates in primary care settings. Objective.
Adriana Maldonado-Franco, Luis F. Giraldo-Cadavid, Eduardo Tuta-Quintero, Alirio R. Bastidas, Angélica Moreno-Giraldo, Daniel A. Botero-Rosas   +5 more
doaj   +1 more source

Fairness, Accuracy, and Unreliable Data

CoRR
This thesis investigates three areas targeted at improving the reliability of machine learning; fairness in machine learning, strategic classification, and algorithmic robustness. Each of these domains has special properties or structure that can complicate learning.
openaire   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Vaccine Logistics Management Information System at Public Health Facilities in Amhara Region, Ethiopia: A Performance Evaluation [PDF]

Healthcare Informatics Research
Objectives This study aimed to evaluate the performance of vaccine logistics management information systems at public health facilities in Amhara Region, Ethiopia. Methods An institution-based concurrent explanatory mixed design was used at public health
Zelalem Tilahun Mekonen, Denny J. Cho, Simon Peter Nadeem, Jose Arturo Garza-Reyes, Teferi Gedif Fenta   +4 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Utilization of Medical Codes for Hypotension in Shock Patients: A Retrospective Analysis

Journal of Multidisciplinary Healthcare, 2021
Charles Hunley,1 Shannon ME Murphy,2 Michael Bershad,2 Halit O Yapici3 1Department of Critical Care Medicine, Orlando Regional Medical Center, Orlando, FL, USA; 2Edwards Lifesciences, Irvine, CA, USA; 3Boston Strategic Partners, Inc., Boston, MA ...
Hunley C, Murphy SME, Bershad M, Yapici HO   +3 more
doaj