Results 51 to 60 of about 27,311,013 (302)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A validity and reliability of the atraumatic care education model questionnaire based on family-centred care in minimising the stress of hospitalisation in children [PDF]

Scripta Medica
Background/Aim: Hospitalisation is a traumatic occurrence in which children must be admitted for acute or chronic diseases. The purpose of this study was to test the validity and reliability of the atraumatic care education model test, instrument based ...
Alfiyanti Dera, Sufyanti Arief Yuni, Krisnana Ilya, Triharini Mira, Pranata Satriya   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Optimizing data collection for obstetrical ultrasound research at the primary health care level in rural Uganda

Global Health Action
Background Neonatal and maternal mortality remains high in low- and middle-income countries (LMIC), especially in sub-Saharan Africa. Quality data collection is crucial to understand the magnitude of these problems and to measure the impact of ...
Renny Ssembatya, Abimbola Leslie, Kristen DeStigter, Erika M. Edwards, Joyce Nayiga, Samalie Nakibirango, Julian P. Arapa, Nicholas Bahati, Blandina Busingye, Thomas Eremu, Mary Nakafeero, Micheal F. Ssenoga, Frank B. Williams, Delia Horn   +13 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Can Automatic Classification Help to Increase Accuracy in Data Collection?

, 2016
Purpose: The authors aim at testing the performance of a set of machine learning algorithms that could improve the process of data cleaning when building datasets.
Diego Chavarro, Yuxian Liu (E-mail: yxliu@tongji.edu.cn)., Frederique Lang, Yuxian Liu   +3 more
core   +1 more source

Data quality, cancer burden, and disparities in oncology care reported in Kinshasa, Democratic Republic of Congo: a retrospective longitudinal descriptive observational study of data from the National Health Information System from 2017 to 2025.

Student's Journal of Health Research Africa
Introduction The availability of high-quality data is an essential condition for quantifying the burden of disease, supporting healthcare decision-making, and rigorously assessing equitable access to oncology care.
Pascal Atuba Mamenepi, Héritier Kalubi Belanga , Jacques Lofandjola Masumbuku, Félicien Ilunga Ilunga, Félicien Tshimungu Kandolo   +4 more
doaj   +1 more source

Accuracy of administrative claims data for polypectomy [PDF]

Canadian Medical Association Journal, 2011
The frequency of polypectomy is an important indicator of quality assurance for population-based colorectal cancer screening programs. Although administrative databases of physician claims provide population-level data on the performance of polypectomy, the accuracy of the procedure codes has not been examined.
Jonathan M, Wyse, Lawrence, Joseph, Alan N, Barkun, Maida J, Sewitch   +3 more
openaire   +2 more sources

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source