Results 41 to 50 of about 2,320,360 (265)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A Probabilistic Data Fusion Modeling Approach for Extracting True Values from Uncertain and Conflicting Attributes

Big Data and Cognitive Computing, 2022
Real-world data obtained from integrating heterogeneous data sources are often multi-valued, uncertain, imprecise, error-prone, outdated, and have different degrees of accuracy and correctness.
Ashraf Jaradat, Fadi Safieddine, Aziz Deraman, Omar Ali, Ahmad Al-Ahmad, Yehia Ibrahim Alzoubi   +5 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Tutorial on Statistical Performance Evaluation Indices: A Review Study [PDF]

Journal of Community Health Research, 2023
Statistical indicators are essential parts of research in many scientific fields such as health and treatment. These indicators play a major role in the evaluation of many health indicators in the general population and can help predict future issues ...
Farzan Madadizadeh, Hooman Yekrang Safakar, Bita Forootani, Malihe Bolukyazdi, Zohreh Khosravani Shooli, Sajjad Bahariniya   +5 more
doaj  

Theoretical Studies and Implementation on the Temporary Data Storage Method for Cone Penetration Test

Sensors, 2021
The traditional cone penetration test system uses cable to transmit data; as the probe goes deeper into the ground, the length of the cable will become longer.
Yanming Li, Yuheng Shen, Xiaoquan Wang, Sifeng Li, Tonglu Li, Quanli Zhao   +5 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Optimizing data collection for obstetrical ultrasound research at the primary health care level in rural Uganda

Global Health Action
Background Neonatal and maternal mortality remains high in low- and middle-income countries (LMIC), especially in sub-Saharan Africa. Quality data collection is crucial to understand the magnitude of these problems and to measure the impact of ...
Renny Ssembatya, Abimbola Leslie, Kristen DeStigter, Erika M. Edwards, Joyce Nayiga, Samalie Nakibirango, Julian P. Arapa, Nicholas Bahati, Blandina Busingye, Thomas Eremu, Mary Nakafeero, Micheal F. Ssenoga, Frank B. Williams, Delia Horn   +13 more
doaj   +1 more source

Quality of Automatic Traffic Volume Counting by Cameras and Impact on the Qualitative Indicators of Traffic

Infrastructures, 2023
This paper presents research on the collection, analysis, and evaluation of the fundamental data needed for road traffic systems. The basis for the research, analysis, planning and projections for traffic systems are traffic counts and data collection ...
Gëzim Hoxha, Arjanit Fandaj, Xhevahir Bajrami   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source