Results 51 to 60 of about 1,249,061 (355)

Cold Storage Data Archives: More Than Just a Bunch of Tapes

open access: yes, 2019
The abundance of available sensor and derived data from large scientific experiments, such as earth observation programs, radio astronomy sky surveys, and high-energy physics already exceeds the storage hardware globally fabricated per year. To that end,
Appuswamy, Raja   +2 more
core   +1 more source

Legal Deposit Web Archives and the Digital Humanities: a Universe of Lost Opportunity? [PDF]

open access: yes, 2018
Legal deposit libraries have archived the web for over a decade. Several nations, supported by legal deposit regu-lations, have introduced comprehensive national domain web crawling, an essential part of the national library re-mit to collect, preserve ...
Berube, Linda   +2 more
core   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Usability of the Management System of Public Libraries of Iran (SAMAN) from the perspective of Visually Impaired Users [PDF]

open access: yesتحقیقات اطلاع‌رسانی و کتابخانه‌های عمومی
Objective: The purpose of this research is to assess the usability of the management system of public libraries (Saman) from the perspective of visually impaired users. Method: The research was applied a formal usability testing.
Azam Najafgholinejad
doaj  

The BRAIN Initiative data-sharing ecosystem: Characteristics, challenges, benefits, and opportunities

open access: yeseLife
In this paper, we provide an overview and analysis of the BRAIN Initiative data-sharing ecosystem. First, we compare and contrast the characteristics of the seven BRAIN Initiative data archives germane to data sharing and reuse, namely data submission ...
Sudhanvan Iyer   +8 more
doaj   +1 more source

Integration of Heterogeneous Shared Data:Yad Vashem’s Perspective as a Data Aggregator

open access: yesUmanistica Digitale, 2019
This paper explains Yad Vashem’s role as a data aggregator, describing its experience in adapting to the changes in the ways data are shared and procured in the present.
Olga Tolokonsky
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Using semantic indexing to improve searching performance in web archives [PDF]

open access: yes, 2013
The sheer volume of electronic documents being published on the Web can be overwhelming for users if the searching aspect is not properly addressed. This problem is particularly acute inside archives and repositories containing large collections of web ...
Khan, Arshad   +2 more
core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

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