Results 151 to 160 of about 192,399 (251)

Model‐Enabled Knowledge Transfer Across Cell Lines, Culture Scales and Conditions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Mechanistic models are central to quantitative understanding and optimization of Chinese hamster ovary (CHO) cell culture processes, but their utility is often restricted by parameter sets calibrated for specific cell lines, scales, or operating conditions.
Luxi Yu, Antonio del Rio Chanona, Cleo Kontoravdi   +2 more
wiley   +1 more source

Validation of an electroencephalography data assimilation-based computational approach for estimating cortical excitation-inhibition balance. [PDF]

Commun Eng
Yokoyama H, Noda Y, Wada M, Takano M, Kitajo K.   +4 more
europepmc   +1 more source

A dataset of winter wheat aboveground biomass in China during 2007-2015 based on data assimilation. [PDF]

Sci Data, 2022
Huang H, Huang J, Li X, Zhuo W, Wu Y, Niu Q, Su W, Yuan W.   +7 more
europepmc   +1 more source

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

Data assimilation reveals behavioral dynamics of sea cucumbers as a model for slow-moving benthic animals. [PDF]

Sci Rep
Takagi T, Tanaka Y, Sasano E, Kanda K, Sakai Y.   +4 more
europepmc   +1 more source

Kinetically Consistent Data Assimilation for Plant PET Sparse Time Activity Curve Signals. [PDF]

Front Plant Sci, 2022
D'Ascenzo N, Xie Q, Antonecchia E, Ciardiello M, Pagnani G, Pisante M.   +5 more
europepmc   +1 more source

Challenges and Future Directives of Synthetic Biology in Engineering Plant–Microbe Partnerships for Sustainable Agriculture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Synthetic biology has recently proven to be a valuable tool for enhancing agriculture even in the face of environmental and biological stresses. Understanding the challenges that militate synthetic biology will assist in ensuring safe, stable, and scalable crop production.
Ben Jesuorsemwen Enagbonma, Rebaona Reaobaka Molefe‐Madlaliso, Alaba Adewole Adebayo, Oghoye Priscilla Oyedoh, Godfrey Okainemen Oribhabor, Oluwaseun Emmanuel Shittu, Olubukola Oluranti Babalola   +6 more
wiley   +1 more source

A data assimilation framework for predicting the spatiotemporal response of high-grade gliomas to chemoradiation. [PDF]

BMC Cancer
Miniere HJM, Hormuth DA, Lima EABF, Farhat M, Panthi B, Langshaw H, Shanker MD, Talpur W, Thrower S, Goldman J, Ty S, Chung C, Yankeelov TE.   +12 more
europepmc   +1 more source

Correction to 'Learning earth system models from observations: machine learning or data assimilation?' [PDF]

Philos Trans A Math Phys Eng Sci, 2022
Geer AJ.
europepmc   +1 more source

Model‐Driven Monitoring and Parameter‐Based Development of an Escherichia coli Fed‐Batch Process for Production of a Fab Antibody Fragment Across Scales

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Maintaining consistent cellular physiology during bioprocess scale‐up or scale‐down is key to developing robust processes. However, the reliability of scale‐down bioreactor systems remains debated. Although the calibration of physiological parameters in mechanistic models across scales has been proposed as a scale‐down strategy, few studies ...
Fabian Schröder‐Kleeberg, Lucas Kaspersetz, Markus Zoellkau, Markus Glaser, Markus Brunner, Christian Bosch, Annina Kemmer, M. Nicolas Cruz Bournazou, Peter Neubauer   +8 more
wiley   +1 more source