Massive data clustering by multi-scale psychological observations. [PDF]
Natl Sci Rev, 2022 Yang S +5 more
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Decoupled GNNs based on multi-view contrastive learning for scRNA-seq data clustering. [PDF]
Brief BioinformYu X, Ren Y, Xia M, Shu Z, Zhu L.
europepmc +1 more source
Fast and Accurate Gamma Imaging System Calibration Based on Deep Denoising Networks and Self-Adaptive Data Clustering. [PDF]
Sensors (Basel), 2023 Zhu Y, Lyu Z, Lu W, Liu Y, Ma T.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Anisotropic DBSCAN for 3D SMLM Data Clustering. [PDF]
J Phys Chem BLörzing P, Schake P, Schlierf M.
europepmc +1 more source
Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
Hands-on training about data clustering with orange data mining toolbox. [PDF]
PLoS Comput BiolDemšar J, Zupan B.
europepmc +1 more source
A Novel COVID-19-Related Drug Discovery Approach Based on Non-Equidimensional Data Clustering. [PDF]
Front Pharmacol, 2022 Chen B, Han Y, Shang X, Zhang S.
europepmc +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source