Results 81 to 90 of about 22,970,744 (375)

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Research on Compression Algorithm of Zone Controller Record DataBased on Huffman Coding

Kongzhi Yu Xinxi Jishu, 2020
Zone controller(ZC) subsystem in the communication based train control(CBTC) system is a full-time continuously working equipment, which is in the center of data interaction of the whole system.
WANG Fuyuan, LEI Chengjian, REN Jianxin
doaj  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Analyses of the Instabilities in the Discretized Diffusion Equations via Information Theory

Entropy, 2016
In a previous investigation (Bigerelle and Iost, 2004), the authors have proposed a physical interpretation of the instability λ = Δt/Δx2 > 1/2 of the parabolic partial differential equations when solved by finite differences.
Maxence Bigerelle, Hakim Naceur, Alain Iost   +2 more
doaj   +1 more source

New scan compression approach to reduce the test data volume

IET Computers & Digital Techniques, 2021
The test data volume (TDV) increases with increased target compression in scan compression and adds to the test cost. Increased TDV is the result of a dependency across scan flip‐flops (SFFs) that resulted from compression architecture, which is absent ...
Pralhadrao V. Shantagiri, Rohit Kapur, Chandrasekar Shastry   +2 more
doaj   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

A Self-Adaptive Compression Method for Ship Trajectories without Threshold Setting

Journal of Marine Science and Engineering
Addressing the shortcomings of existing ship trajectory compression methods that rely on the empirical setting of a fixed threshold and face challenges in controlling the spatial similarity before and after compression, this paper proposes a self ...
Lihua Zhang, Yinfei Zhou, Lulu Tang, Shuaidong Jia, Zeyuan Dai   +4 more
doaj   +1 more source

LiftingWiSe: A Lifting-Based Efficient Data Processing Technique in Wireless Sensor Networks

Sensors, 2014
Monitoring thousands of objects which are deployed over large-hard-to-reach areas, is an important application of the wireless sensor networks (WSNs). Such an application requires disseminating a large amount of data within the WSN.
Emad Aboelela
doaj   +1 more source

Capturing Regular Human Activity through a Learning Context Memory [PDF]

, 2006
A learning context memory consisting of two main parts is presented. The first part performs lossy data compression, keeping the amount of stored data at a minimum by combining similar context attributes — the compression rate for the presented GPS ...
Mohr, Philipp H., Ryan, Nick S., Timmis, Jon   +2 more
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