Results 31 to 40 of about 1,356,133 (201)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Researchers May Need Additional Data Curation Support
Evidence Based Library and Information Practice, 2019 A Review of: Johnston, L. R., Carlson, J., Hudson-Vitale, C., Imker, H., Kozlowski, W., Olendorf, R., & Stewart, C. (2018). How important are data curation activities to researchers? Gaps and opportunities for academic libraries.
Robin E. Miller
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
From complex histories to cohesive data, a long-term agricultural dataset from the Morrow Plots
Scientific DataLong-term agricultural experiments are essential to measure the impacts of farming practices on crop yields, soil fertility and biogeochemical processes. However, these impacts often only manifest at decadal timescales, requiring committed and consistent
Sandi L. Caldrone +2 more
doaj +1 more source
Social science research data curation
Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2017 Data curation is attracting a growing interest in the library and information science community. The main purpose of data curation is to support data reuse.
Guangyuan Sun, Christopher S.G Khoo
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
BMC Musculoskeletal DisordersBackground The impact of patellar resurfacing (PR) on long-term outcomes following primary total knee arthroplasty (TKA) remains a topic of debate.
Diego Laverde Osorio +6 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source