Results 51 to 60 of about 1,366,867 (247)
BMC Musculoskeletal DisordersBackground The impact of patellar resurfacing (PR) on long-term outcomes following primary total knee arthroplasty (TKA) remains a topic of debate.
Diego Laverde Osorio +6 more
doaj +1 more source
, 2009 Nereus is a consortium of prestigious European libraries in the world of academic economics. At present the consortium concentrates its efforts on a EU funded project called NEEO (Network of European Economists Online) which will address the lack of integration of academic output by creating a powerful new research tool called Economists Online.
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Data Curation: Towards a Tool for All [PDF]
, 2020 Data science has started to become one of the most important skills one can have in the modern world, due to data taking an increasingly meaningful role in our lives. The accessibility of data science is however limited, requiring complicated software or programming knowledge. Both can be challenging and hard to master, even for the simple tasks.
José Dias, Jácome Cunha, Rui Pereira
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Extending the Research Data Toolkit: Data Curation Primers
International Journal of Digital Curation, 2020 Niche and proprietary data formats used in cutting-edge research and technology have specific curation considerations and challenges. The increased demand for subject liaisons, library archivists, and digital curators to curate this variety of data types
Cynthia Hudson-Vitale +7 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source