Results 61 to 70 of about 1,366,867 (247)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Data Curation and the Arts: How Do Musicians Curate Their Data?

Music Reference Services Quarterly, 2016
Professional musicians were surveyed to determine how personal, amateur recordings of performances are shared with students and colleagues.
Amy S. Jackson, Jonathan Wheeler, Todd Quinn   +2 more
openaire   +2 more sources

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The Impact of The HER2 Status (HER2 Low Vs HER2-Zero) On the Pathological Response to Neoadjuvant Chemotherapy in Hormonal Receptor Positive Breast Cancer [PDF]

Ain Shams Medical Journal
Background: The term "Human epidermal growth factor receptor 2 (HER2) low breast cancer (BC)" is being used to describe more than 50% of breast cancer cases.
Nourhan El-haroun, Mahmoud Ellithy, Thanaa Helal, Mohamed Mustafa, Ahmed Abdel-Aziz, Hagar Elghazawy   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Data Curation oder (Retro) Digitalisierung ist mehr als die Produktion von Daten

o-bib. Das offene Bibliotheksjournal, 2015
Nahezu jede Bibliothek, die über Altbestand verfügt, beschäftigt sich heute mit dem Thema Digitalisierung. Dabei wird oftmals übersehen, dass die dauerhafte und möglichst nutzerfreundliche Bereitstellung (und letztlich die Archivierung) der erzeugten ...
Klaus Kempf
doaj   +1 more source

Data curations by the Dutch Data Curation Service: Overview and future perspective. [PDF]

, 2015
Contains fulltext : 150245.pdf (Publisher’s version ) (Open Access)
Heuvel, H. van den, Oostdijk, N.H.J., Sanders, E.P., Lint, V. de   +3 more
openaire   +1 more source

The Data Curation Network: Leveraging Expertise to Curate Data at Scale

, 2019
The Data Curation Network launched the three-year pilot of a distributed model for the curation of research data in 2018. Good curation increases the value and impact of research data. The collaborative, networked approach of the Data Curation Network leverages the expertise across network members to enhance the local repository’s ability to curate ...
Blake, Mara, Herndon, Joel
openaire   +2 more sources

Data curation profiling of biocollections

Proceedings of the Association for Information Science and Technology, 2016
ABSTRACT In the contexts of the data deluge and open data, scientists studying biodiversity benefit from online access to global datasets of existing vouchered biological and paleontological collections. Using biocollections collected over time across the world allows for the advancement of scientific knowledge concerning evolution in
Bradley Wade Bishop, Carolyn Hank
openaire   +1 more source