Results 61 to 70 of about 25,162,578 (291)
Social science research data curation
Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2017 Data curation is attracting a growing interest in the library and information science community. The main purpose of data curation is to support data reuse.
Guangyuan Sun, Christopher S.G Khoo
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
BMC Musculoskeletal DisordersBackground The impact of patellar resurfacing (PR) on long-term outcomes following primary total knee arthroplasty (TKA) remains a topic of debate.
Diego Laverde Osorio +6 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Data Curation: Towards a Tool for All [PDF]
, 2020 Data science has started to become one of the most important skills one can have in the modern world, due to data taking an increasingly meaningful role in our lives. The accessibility of data science is however limited, requiring complicated software or programming knowledge. Both can be challenging and hard to master, even for the simple tasks.
José Dias, Jácome Cunha, Rui Pereira
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Extending the Research Data Toolkit: Data Curation Primers
International Journal of Digital Curation, 2020 Niche and proprietary data formats used in cutting-edge research and technology have specific curation considerations and challenges. The increased demand for subject liaisons, library archivists, and digital curators to curate this variety of data types
Cynthia Hudson-Vitale +7 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source