Results 71 to 80 of about 3,447,982 (286)

Global socioeconomic inequalities in vaccination coverage, supply, and confidence

npj Vaccines
Sustainable Development Goal (SDG) adopted in 2015 aim to reduce inequalities and achieve universal health coverage, including access to essential vaccines for all.
Qiang Wang, Kathy Leung, Mark Jit, Joseph T. Wu, Leesa Lin   +4 more
doaj   +1 more source

Reconstructing Sessions from Data Discovery and Access Logs to Build a Semantic Knowledge Base for Improving Data Discovery

ISPRS International Journal of Geo-Information, 2016
Big geospatial data are archived and made available through online web discovery and access. However, finding the right data for scientific research and application development is still a challenge. This paper aims to improve the data discovery by mining
Yongyao Jiang, Yun Li, Chaowei Yang, Edward M. Armstrong, Thomas Huang, David Moroni   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Regulatory roles of three-dimensional structures of chromatin domains

Genome Biology
Background Transcriptional enhancers usually, but not always, regulate genes within the same topologically associating domain (TAD). We hypothesize that this incomplete insulation is partially due to three-dimensional structures of corresponding ...
Kelly Yichen Li, Qin Cao, Savio Ho-Chit Chow, Chiara Nicoletti, Pier Lorenzo Puri, Huating Wang, Danny Leung, Kevin Y. Yip   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Pretraining graph transformers with atom-in-a-molecule quantum properties for improved ADMET modeling

Journal of Cheminformatics
We evaluate the impact of pretraining Graph Transformer architectures on atom-level quantum-mechanical features for the modeling of absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of drug-like compounds.
Alessio Fallani, Ramil Nugmanov, Jose Arjona-Medina, Jörg Kurt Wegner, Alexandre Tkatchenko, Kostiantyn Chernichenko   +5 more
doaj   +1 more source

Augmenting Retail Data With Open Data for Smarter Tourism Destinations

IEEE Access
The current tourism landscape intertwines physical and digital realms, giving rise to smart tourism. This paradigm shift leverages technology, generating large amounts of data from sensors and mobile devices, offering vast opportunities for strategic ...
Olimpia Alcaraz, Alberto Berenguer, David Tomas, Marcos A. Celdran-Bernabeu, Jose-Norberto Mazon   +4 more
doaj   +1 more source

The Smallest Grammar Problem as Constituents Choice and Minimal Grammar Parsing

Algorithms, 2011
The smallest grammar problem—namely, finding a smallest context-free grammar that generates exactly one sequence—is of practical and theoretical importance in fields such as Kolmogorov complexity, data compression and pattern discovery.
Gabriel Infante-Lopez, Rafael Carrascosa, Matthias Gallé, François Coste   +3 more
doaj   +1 more source

Patterns for searching data on the web across different research communities

Liber Quarterly: The Journal of European Research Libraries, 2020
Being a concept quite familiar in the domain of information retrieval, data search in a web based environment has recently gained attention. With researchers and academic institutions increasingly publishing their data on the public web, traditional ...
Timo Borst, Fidan Limani
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source