Results 81 to 90 of about 3,447,982 (286)
Bridging the Data Discovery Gap: User-Centric Recommendations for Research Data Repositories
Data Science JournalDespite substantial investment in research data infrastructure, data discovery remains a fundamental challenge in the era of open science. The proliferation of repositories and the rapid growth of deposited data have not resulted in a corresponding ...
Mingfang Wu +14 more
doaj +1 more source
Data-driven discovery of coordinates and governing equations
, 2019 The discovery of governing equations from scientific data has the potential to transform data-rich fields that lack well-characterized quantitative descriptions.
Brunton, Steven L. +3 more
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Big Earth Data, 2019 In the research field of spatiotemporal data discovery, how to utilize the semantic characteristics of spatiotemporal datasets is an important topic. This paper presented a content-based recommendation method, and applied Bayesian networks and ontologies
Kejin Cui +3 more
doaj +1 more source
Generating predictions to aid the scientific discovery process [PDF]
, 1986 NGLAUBER is a system which models the scientific discovery of qualitative empirical laws. As such, it falls into the category of scientific discovery systems.
Jones, Randy
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
A Transformative Concept: From Data Being Passive Objects to Data Being Active Subjects
Data, 2019 The exploitation of potential societal benefits of Earth observations is hampered by users having to engage in often tedious processes to discover data and extract information and knowledge.
Hans-Peter Plag, Shelley-Ann Jules-Plag
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source