Results 91 to 100 of about 4,922,883 (290)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Integration of survey data and big observational data for finite population inference using mass imputation [PDF]

, 2018
Multiple data sources are becoming increasingly available for statistical analyses in the era of big data. As an important example in finite-population inference, we consider an imputation approach to combining a probability sample with big observational
Kim, Jae Kwang, Kim, Jae Kwang, Yang, Shu   +2 more
core   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

CIDACS' efforts towards an inclusive and dialogic data governance in Brazil: a focused literature review

International Journal of Population Data Science
The Centre for Data and Knowledge Integration for Health's (CIDACS) data governance efforts have primarily focused on legal, technical and operational procedures to provide high-quality linked administrative data for investigations on social ...
Bethania de Araujo Almeida, Roberto Carreiro, Maìra Souza, Mauricio Barreto   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Improving data driven decision making through integration of environmental sensing technologies [PDF]

, 2013
Coastal and estuarine zones contain vital and increasingly exploited resources. Traditional uses in these areas (transport, fishing, tourism) now sit alongside more recent activities (mineral extraction, wind farms). However, protecting the resource base
Briciu Burghina, Ciprian Constantin, Gualano, Leonardo, Heery, Brendan, O'Connor, Edel, O'Connor, Noel E., Regan, Fiona, Smeaton, Alan F., Sullivan, Timothy, Zhang, Jian   +8 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Minha Casa Minha Vida social housing programme and leprosy in Brazil: an analysis of the 100 Million Brazilian Cohort (2010–2015)

BMC Public Health
Background Ensuring housing interventions can contribute to improved living conditions which are strong socioeconomic determinants of leprosy. We estimated the association between the social housing programme Minha Casa Minha Vida (MCMVP) and leprosy new
Camila S. S. Teixeira, Júlia M. Pescarini, Mauro N. Sanchez, Andrêa Jacqueline F. Ferreira, Rosemeire L. Fiaccone, Maria Yury Ichihara, Renzo Flores-Ortiz, Elizabeth B. Brickley, Peter Craig, Alastair H. Leyland, Srinivasa Vittal Katikireddi, Maria Lucia F. Penna, Gerson O. Penna, Rita de Cássia Ribeiro-Silva, Maurício L. Barreto   +14 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Provenance in Linked Data Integration

, 2010
The open world of the (Semantic) Web is a global information space offering diverse materials of disparate qualities, and the opportunity to re-use, aggregate, and integrate these materials in novel ways. The advent of Linked Data brings the potential to
Gibbins, Nicholas, Omitola, Temitope, Shadbolt, Nigel   +2 more
core