Results 101 to 110 of about 4,922,883 (290)

Mediated data integration and transformation for web service-based software architectures [PDF]

, 2006
Service-oriented architecture using XML-based web services has been widely accepted by many organisations as the standard infrastructure to integrate heterogeneous and autonomous data sources.
Pahl, Claus, Zhu, Yaoling
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Pathways to suicide prevention: a population-based cohort study of the mediating role of Bolsa Família in psychosocial stressors in the 100 million Brazilian cohort

BMJ Public Health
Introduction Suicide is a major public health concern in Brazil, and its risk is heightened by psychosocial stressors disproportionately affecting socioeconomically vulnerable groups.
Maurício Lima Barreto, Flávia Jôse Oliveira Alves, Patrícia Fortes Cavalcanti de Macêdo, Gilciane Ceolin, Rumenick Pereira Silva, Luis F S Castro-de-Araujo, Daiane B Machado   +6 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Combining machine learning and dynamic system techniques to early detection of respiratory outbreaks in routinely collected primary healthcare records

BMC Medical Research Methodology
Background Methods that enable early outbreak detection represent powerful tools in epidemiological surveillance, allowing adequate planning and timely response to disease surges.
Dérick G. F. Borges, Eluã R. Coutinho, Thiago Cerqueira-Silva, Malú Grave, Adriano O. Vasconcelos, Luiz Landau, Alvaro L. G. A. Coutinho, Pablo Ivan P. Ramos, Manoel Barral-Netto, Suani T. R. Pinho, Marcos E. Barreto, Roberto F. S. Andrade   +11 more
doaj   +1 more source

Rapid weight gain in first 2 years of life and BMI trajectories from 3 to <10 years: a population-based longitudinal study of 1.7 million Brazilian childrenResearch in context

The Lancet Regional Health. Americas
Summary: Background: Obesity is considered a disease with negative health impacts at all life stages. Changes in growth patterns, such as postnatal rapid weight gain (RWG), can be important predictors of growth trajectories in children.
Carolina Santiago-Vieira, Leah Li, Rita de Cássia Ribeiro Silva, Juliana Freitas de Mello e Silva, Enny S. Paixão, Maurício L. Barreto, Gustavo Velasquez-Melendez   +6 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source