Results 101 to 110 of about 4,962,296 (289)

Viking lander design and systems integration [PDF]

, 1974
Malfunction protection requires redundancy planning and mechanization in Viking lander design and systems integration in order to maximize the chance of getting the data back through the Orbiter. Various subsystems are discussed that protect the downlink
Goodlette, J.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Minha Casa Minha Vida social housing programme and leprosy in Brazil: an analysis of the 100 Million Brazilian Cohort (2010–2015)

BMC Public Health
Background Ensuring housing interventions can contribute to improved living conditions which are strong socioeconomic determinants of leprosy. We estimated the association between the social housing programme Minha Casa Minha Vida (MCMVP) and leprosy new
Camila S. S. Teixeira, Júlia M. Pescarini, Mauro N. Sanchez, Andrêa Jacqueline F. Ferreira, Rosemeire L. Fiaccone, Maria Yury Ichihara, Renzo Flores-Ortiz, Elizabeth B. Brickley, Peter Craig, Alastair H. Leyland, Srinivasa Vittal Katikireddi, Maria Lucia F. Penna, Gerson O. Penna, Rita de Cássia Ribeiro-Silva, Maurício L. Barreto   +14 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Pathways to suicide prevention: a population-based cohort study of the mediating role of Bolsa Família in psychosocial stressors in the 100 million Brazilian cohort

BMJ Public Health
Introduction Suicide is a major public health concern in Brazil, and its risk is heightened by psychosocial stressors disproportionately affecting socioeconomically vulnerable groups.
Maurício Lima Barreto, Flávia Jôse Oliveira Alves, Patrícia Fortes Cavalcanti de Macêdo, Gilciane Ceolin, Rumenick Pereira Silva, Luis F S Castro-de-Araujo, Daiane B Machado   +6 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Combining machine learning and dynamic system techniques to early detection of respiratory outbreaks in routinely collected primary healthcare records

BMC Medical Research Methodology
Background Methods that enable early outbreak detection represent powerful tools in epidemiological surveillance, allowing adequate planning and timely response to disease surges.
Dérick G. F. Borges, Eluã R. Coutinho, Thiago Cerqueira-Silva, Malú Grave, Adriano O. Vasconcelos, Luiz Landau, Alvaro L. G. A. Coutinho, Pablo Ivan P. Ramos, Manoel Barral-Netto, Suani T. R. Pinho, Marcos E. Barreto, Roberto F. S. Andrade   +11 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source