Results 111 to 120 of about 1,389,848 (316)

Crowdsourcing the world: solving real-world problems with data from the crowd

open access: yes, 2016
Presented at the National data integrity conference: data sharing: the how, why, when and when not to share held on June 2-3, 2016 at University of Colorado, Denver, Colorado.
Barrington, Luke, author
core   +1 more source

Married 6-year olds and other diseases of data [PDF]

open access: yes, 2015
Presented at the National data integrity conference: enabling research: new challenges & opportunities held on May 7-8, 2015 at Colorado State University, Fort Collins, Colorado.
Kahn, Michael G., author   +1 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

A brief history of unicorn husbandry and other magical wonders: data and the library

open access: yes, 2016
Presented at the National data integrity conference: data sharing: the how, why, when and when not to share held on June 2-3, 2016 at University of Colorado, Denver, Colorado.
Wirz, Jackie, author   +1 more
core   +1 more source

GeoLedger: blockchain and GIS architecture for trusted emergency incident mapping

open access: yesFrontiers in Blockchain
Most existing emergency management systems are centralized, leaving critical information vulnerable to unauthorized access, manipulation, and single points of failure.
Osama A. Khashan
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Link integrity for the Semantic Web

open access: yes, 2012
The usefulness and usability of data on the Semantic Web is ultimately reliant on the ability of clients to retrieve Resource Description Framework (RDF) data from the Web.
Vesse, Robert
core  

Standardising Data Quality in IoT-to-AI Workflows: A Formal Multilayered Architecture for Reliable and Quality-Assured Information Systems

open access: yesApplied Sciences
This paper presents the Data Quality Assurance Model (DQAM), a formal model and multilayered architecture designed to guarantee data integrity and robustness in Reliable and Quality-Assured Information Systems.
Lucia Arnau Muñoz   +3 more
doaj   +1 more source

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