Results 81 to 90 of about 2,828,600 (279)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Irrigation in Precision Agriculture Using Blockchain Ethereum Based on IoT
Engineering ProceedingsThe primary objective of this project is to develop a robust and secure system that uses blockchain technology as well as Ethereum and IoT sensors to create a transparent and automated irrigation management solution for farmers.
Sri Sai Durga Mani Vasireddy +6 more
doaj +1 more source
Cyber-risk insurance — a big challenge facing contemporary economies [PDF]
Revista de Studii Financiare, 2019 Cyber-security beyond the concept must be a product to be offered to modern society. We live in a complex world based on the digitization of products and services. Digitization also involves a complex system of associated risks.
CALIN Mihai Rangu, Leonardo Badea
doaj
A threshold secure data sharing scheme for federated clouds
, 2012 Cloud computing allows users to view computing in a new direction, as it uses the existing technologies to provide better IT services at low-cost.
Padmavathamma, M., Venkataramana, K.
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Can Integrity Replace Institutions? Theory and Evidence [PDF]
Institutions are important for proper economic performance, but are replaceable by trust or other social norms. We show that when proper institutions and trust are missing, integrity of the individuals can replace them.
Faysal Fahs +2 more
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Artificial intelligence for cancer screening and surveillance
ESMO Real World Data and Digital OncologyInvesting in cancer prevention can be cost-effective. However, this requires significant changes both inside and outside the health care system. The core of the preventive strategy is the assignment of an individual risk level of developing cancer ...
F. Gentile, N. Malara
doaj +1 more source