Results 91 to 100 of about 2,756,498 (272)

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Probabilistic Method to Fuse Artificial Intelligence-Generated Underground Utility Mapping

Sensors
Utility as-built plans, which typically provide information about underground utilities’ position and spatial locations, are known to comprise inaccuracies.
Kunle Sunday Oguntoye, Simon Laflamme, Roy Sturgill, Daniel A. Salazar Martinez, David J. Eisenmann, Anne Kimber   +5 more
doaj   +1 more source

Common pitfalls in statistical analysis: The perils of multiple testing

Perspectives in Clinical Research, 2016
Multiple testing refers to situations where a dataset is subjected to statistical testing multiple times - either at multiple time-points or through multiple subgroups or for multiple end-points. This amplifies the probability of a false-positive finding.
Priya Ranganathan, C S Pramesh, Marc Buyse   +2 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Sparse Autoencoders Can Interpret Randomly Initialized Transformers [PDF]

arXiv
Sparse autoencoders (SAEs) are an increasingly popular technique for interpreting the internal representations of transformers. In this paper, we apply SAEs to 'interpret' random transformers, i.e., transformers where the parameters are sampled IID from a Gaussian rather than trained on text data.
arxiv  

INTERPRETATION OF LIGHT SCATTERING DATA OBTAINED FROM SOLUTIONS OF LARGE ROD-LIKE PARTICLES [PDF]

, 1959
M.E. Reichmann
openalex   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

The Interpretation and Application of Whole Core Analysis Data on Carbonate Reservoirs [PDF]

, 1957
Ralph E. Jenkins, W.R. Aufricht
openalex   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Children's cognitive reflection predicts successful interpretations of covariation data

Frontiers in Developmental Psychology
IntroductionCognitive reflection is the ability and disposition to reflect on one's own thinking, allowing a person to identify and correct judgments grounded in intuition rather than logic.
Andrew G. Young, Andrew Shtulman
doaj   +1 more source