Results 121 to 130 of about 28,657,076 (302)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Data compilation regarding the effects of grain size and temperature on the strength of the single-phase FCC CrFeNi medium entropy alloy

, 2020
In the present article, we present a data compilation reflecting recrystallized microstructures and the corresponding mechanical properties of an equiatomic, single-phase faced-centered cubic (FCC) CrFeNi medium-entropy alloy (MEA).
Schneider, M (via Mendeley Data), Schneider, Mike   +1 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Table S21 - Paleomagnetic data interpretation from ODP Site 208-1262

, 2017
Table S21 - Paleomagnetic data interpretation from ODP Site 208 ...
James C Zachos (6958619), Westerhold, Thomas, Wilkens, Roy H, Isabella Raffi (6961205), Roy H Wilkens (6963410), Agnini, Claudia, Thomas Frederichs (6965138), Ursula Röhl (6959540), Frederichs, Thomas, Raffi, Isabella, Röhl, Ursula, Zachos, James C, Thomas Westerhold (6960026), Claudia Agnini (7908953)   +13 more
core   +1 more source

Measuring. Monitoring. Management. Control

Измерение, мониторинг, управление, контроль
Background. The emergence and importance of the research topic is substantiated by the colossal growth in the volume of accumulated and underprocessed medical information, the evolution of mathematical and algorithmic apparatus, and the need to improve
M.V. Sprindzuk, V.I. Bernik, A.P. Konchits   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Table S23 - Paleomagnetic data interpretation from ODP Site 208-1265

, 2017
Table S23 - Paleomagnetic data interpretation from ODP Site 208 ...
James C Zachos (6958619), Westerhold, Thomas, Wilkens, Roy H, Isabella Raffi (6961205), Roy H Wilkens (6963410), Agnini, Claudia, Thomas Frederichs (6965138), Ursula Röhl (6959540), Frederichs, Thomas, Raffi, Isabella, Röhl, Ursula, Zachos, James C, Thomas Westerhold (6960026), Claudia Agnini (7908953)   +13 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source