Results 121 to 130 of about 2,534,579 (265)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Methodological guidelines for P2X receptor assays and data interpretation. [PDF]

Cell Death Dis
Gorecki DC, Adinolfi E, Adriouch S, Coutinho-Silva R, Engel T, Gölöncsér F, Haag F, Illes P, Jacobson KA, Koch-Nolte F, Mansoor SE, Matute C, Melino G, Novak I, Pegoraro A, Pelegrin P, Piacentini M, Robson SC, Rumney RMH, Seman M, Sluyter R, Sperlagh B, Tang Y, Tarantini M, Ulrich H, Vouret-Craviari V, Ye Q, Yegutkin GG, Verkhratsky A.   +28 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Calcium Buffering in Astrocytes and Its Relevance for Experimental Data Interpretation and Computational Modeling. [PDF]

J Neurochem
Lenk K, Zeug A, Müller FE.
europepmc   +1 more source

OpenXGR: a web-server update for genomic summary data interpretation. [PDF]

Nucleic Acids Res, 2023
Bao C, Wang S, Jiang L, Fang Z, Zou K, Lin J, Chen S, Fang H.   +7 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Editorial: Neuromorphic and deep learning paradigms for neural data interpretation and computational neuroscience. [PDF]

Front Comput Neurosci
Zou C, Yuan R, Wen J.
europepmc   +1 more source

Advancing Evidence-Based Data Interpretation in UV-Vis and Fluorescence Analysis for Nanomaterials: An Analytical Chemistry Perspective. [PDF]

Anal Chem, 2023
Wamsley M, Zou S, Zhang D.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

PubMatcher: a web app to support genomic data interpretation through simplified bibliographic research. [PDF]

Eur J Hum Genet
Marin V, Lannes H, Dumont V, Thevenon J, Baux D, Roux AF, Lasseaux E, Pennamen P, Lebreton L.   +8 more
europepmc   +1 more source