Results 91 to 100 of about 32,290,400 (291)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin +2 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Data Management Plan I is a public version of a deliverable of the Horizon Europe project PEACE. The original deliverable was delivered to the granting authority, Clean Hydrogen Partnership, in August 2023. The PEACE DMP is guided by the EU Open Science policy and Horizon Europe Data Management Plan obligations.
openaire +2 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Seven Recommendations to Make Your Invasive Alien Species Data More Useful
Frontiers in Applied Mathematics and Statistics, 2017 Science-based strategies to tackle biological invasions depend on recent, accurate, well-documented, standardized and openly accessible information on alien species.
Quentin J. Groom +29 more
doaj +1 more source
Planning and Managing Research Data: How to Create a Data Management Plan
CIIMAR Course: Planning and Managing Research Data: How to Create a Data Management Plan | May 16th + 20th 2025 | in person Planning and Managing Research Data: How to Create a Data Management Plan course, organized by CIIMAR, will take place at CIIMAR on may 16th and 20th 2025.
Interdisciplinary Centre of Marine and Environmental Research +1 more
openaire +3 more sources
Data Management Plan (DMP) [PDF]
This data management plan (DMP) describes how the Safety through Disruption (Safe-D) National University Transportation Center (UTC) will comply with the U.S.
Virginia Polytechnic Institute and State University
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