Results 31 to 40 of about 25,216,828 (261)

An Improved Heteroscedastic Modeling Method for Chest X-ray Image Classification with Noisy Labels

Algorithms, 2023
Chest X-ray image classification suffers from the high inter-similarity in appearance that is vulnerable to noisy labels. The data-dependent and heteroscedastic characteristic label noise make chest X-ray image classification more challenging. To address
Qingji Guan, Qinrun Chen, Yaping Huang
doaj   +1 more source

Distributed classification for pocket data mining [PDF]

, 2011
Distributed and collaborative data stream mining in a mobile computing environment is referred to as Pocket Data Mining PDM. Large amounts of available data streams to which smart phones can subscribe to or sense, coupled with the increasing ...
Philip S. Yu, Liu, Han, Bramer, M., Mohamed Medhat Gaber, Max Bramer, Gaber, M., Han Liu, Yu, P., Frederic Stahl, Yu, P. S., Stahl, F., Stahl, Frederic, Bramer, Max, Gaber, M. M., Liu, H.   +14 more
core   +1 more source

Radiogenomic-based prediction of genetic alterations in oncogenic signaling pathways in lung cancer

Egyptian Journal of Medical Human Genetics
Rationale and objectives Lung adenocarcinoma, a type of non-small cell lung cancer (NSCLC), originates from the peripheral lung tissue and is the most prevalent histologic subtype, constituting around 40% of cases.
Priyadharshini Jayachandran, Gowtham Murugesan, Jeyakumar Natarajan   +2 more
doaj   +1 more source

A comprehensive evaluation of module detection methods for gene expression data

Nature Communications, 2018
Modules composed of groups of genes with similar expression profiles tend to be functionally related and co-regulated. Here, Saelens et al evaluate the performance of 42 computational methods and provide practical guidelines for module detection in gene ...
Wouter Saelens, Robrecht Cannoodt, Yvan Saeys   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Ubiquitous data stream mining [PDF]

, 2004
The dissemination of data stream systems, wireless networks and mobile devices motivates the need for an efficient data analysis tool capable of gaining insights about these continuous data streams.
Zaslavsky, Arkady, Krishnaswamy, S., Krishnaswamy, Shonali, Gaber, M., Gaber, Mohamed M, Zaslavsky, A.   +5 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Anticipating On‐Target and Off‐Target Effects of CRISPR/Cas9 Genome Editing Via a Feedforward Neural Network Model

Medicine Advances
Background Clustered regularly interspaced short palindromic repeats —CRISPR‐associated protein 9 (CRISPR/Cas9) is a gene editing technology that can deliver highly precise genome editing.
Pavithra Nagendran, Gowtham Murugesan, Jeyakumar Natarajan   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source