Results 41 to 50 of about 23,785,135 (371)

Radiogenomic-based prediction of genetic alterations in oncogenic signaling pathways in lung cancer

open access: yesEgyptian Journal of Medical Human Genetics
Rationale and objectives Lung adenocarcinoma, a type of non-small cell lung cancer (NSCLC), originates from the peripheral lung tissue and is the most prevalent histologic subtype, constituting around 40% of cases.
Priyadharshini Jayachandran   +2 more
doaj   +1 more source

A comprehensive evaluation of module detection methods for gene expression data

open access: yesNature Communications, 2018
Modules composed of groups of genes with similar expression profiles tend to be functionally related and co-regulated. Here, Saelens et al evaluate the performance of 42 computational methods and provide practical guidelines for module detection in gene ...
Wouter Saelens   +2 more
doaj   +1 more source

Efficient Analysis of Pattern and Association Rule Mining Approaches

open access: yes, 2014
The process of data mining produces various patterns from a given data source. The most recognized data mining tasks are the process of discovering frequent itemsets, frequent sequential patterns, frequent sequential rules and frequent association rules.
Lazzez, Amor, Slimani, Thabet
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Automatic Landform Recognition from the Perspective of Watershed Spatial Structure Based on Digital Elevation Models

open access: yesRemote Sensing, 2021
Landform recognition is one of the most significant aspects of geomorphology research, which is the essential tool for landform classification and understanding geomorphological processes.
Siwei Lin, Nan Chen, Zhuowen He
doaj   +1 more source

Response to allopurinol and febuxostat according to the fractional excretion of urate in men with gout

open access: yesArthritis Care &Research, Accepted Article.
Background Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of urate (FEUA) also modulates this response and relates to oxypurinol concentrations. We further evaluated its potential influence
Pascal Richette   +13 more
wiley   +1 more source

Anticipating On‐Target and Off‐Target Effects of CRISPR/Cas9 Genome Editing Via a Feedforward Neural Network Model

open access: yesMedicine Advances
Background Clustered regularly interspaced short palindromic repeats —CRISPR‐associated protein 9 (CRISPR/Cas9) is a gene editing technology that can deliver highly precise genome editing.
Pavithra Nagendran   +2 more
doaj   +1 more source

Role of Prednisone and 25(OH) Vitamin D on Bone Mineral Density and Osteoporosis in Systemic Lupus Erythematosus

open access: yesArthritis Care &Research, Accepted Article.
Objective We evaluated the role of 25‐hydroxy vitamin D, prednisone and other risk factors for bone mineral density (BMD) loss and osteoporosis in systemic lupus erythematosus (SLE). Methods We calculated the association between 25‐hydroxy vitamin D [25(OH)D] levels and other potential risk factors with BMD measures (spine T‐scores) and osteoporosis ...
Nima Madanchi   +4 more
wiley   +1 more source

Combining Three Peripheral Blood Biomarkers to Stratify Rheumatoid Arthritis‐Associated Interstitial Lung Disease Risk

open access: yesArthritis Care &Research, Accepted Article.
Objective The purpose was to evaluate a biomarker score consisting of MUC5B rs35705950 promoter variant, plasma matrix metalloproteinase (MMP)‐7, and serum anti‐malondialdehyde‐acetaldehyde (anti‐MAA) antibody for RA‐associated interstitial lung disease risk stratification. Methods Using a multicenter cohort of US veterans with RA, we performed a cross‐
Kelsey Coziahr   +16 more
wiley   +1 more source

A machine-learning-based hardware-Trojan detection approach for chips in the Internet of Things

open access: yesInternational Journal of Distributed Sensor Networks, 2019
With the development of the Internet of Things, smart devices are widely used. Hardware security is one key issue in the security of the Internet of Things.
Chen Dong   +3 more
doaj   +1 more source

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