Results 101 to 110 of about 1,987,834 (344)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

IMPLEMENTASI PENGAWASAN TAHAPAN PEMUTAKHIRAN DATA PEMILIH (DPT) DALAM PEMILU KEPALA DAERAH KOTA MEDAN TAHUN 2010 (STUDI KASUS KELURAHAN PUSAT PASAR KECAMATAN MEDAN KOTA KOTA MEDAN)

Perspektif: Jurnal Ilmu-ilmu Sosial, 2019
The successful implementation of the policy will be determined by many variables or factors, and each of these variables are related to one another. In view of Edwards III, policy implementation is influenced by four variables, namely: (1) communication,
David Susanto
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

The Influence of Audit Tenure and Audit Committee on Earnings Quality

Jurnal Akuntansi, Manajemen dan Ekonomi, 2017
One of the Auditor and Audit committee role is to ensure the quality of corporate financial reporting process. This study aims to test the effect of the length of auditor tenure and audit committee on earning quality measured by the absolute value of ...
Fatima Zakiya Razani, Liu Xia
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A joint industry-sponsored data monitoring committee model for observational, retrospective drug safety studies in the real-world setting. [PDF]

Pharmacoepidemiol Drug Saf, 2021
Major-Pedersen A, McCullen MK, Sabol ME, Adetunji O, Massaro J, Neugut AI, Sosa JA, Hollenberg AN.   +7 more
europepmc   +1 more source

Audit and Risk Management Committee Charter of the Consortium Board [PDF]

, 2014
The Audit and Risk Management Committee (ARC) is responsible for assisting the Consortium Board to fulfill its oversight responsibilities in relation to (i) monitoring the quality and integrity of both financial and operational reporting by CRP Lead ...
CGIAR Consortium Board
core   +1 more source

Data Monitoring Committees and clinical trials: From scientific justification to organisation

, 2023
Clara Locher, Silvy Laporte, Peggy Derambure, Olivier Chassany, Cécile Girault, Alix Avakiantz, Claire Bahans, Dominique Deplanque, Pierre Fustier, Anne-Françoise Germe, Behrouz Kassaï, L. Lacoste, Nadine Petitpain, Matthieu Roustit, Tabassome Simon, Cécile Train, Michel Cucherat   +16 more
openalex   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Enhancing clarity of clinical trial safety reports for data monitoring committees [PDF]

, 2020
Sonia Thomas, Kwanhye Jung, Hengrui Sun, Matthew A. Psioda, P. Miguel Quibrera, Stephen M. Strakowski   +5 more
openalex   +1 more source