PRIMA: randomized prospective multicenter non-inferiority study for primary diagnosis of clinically significant PRostate cancer by PSA and MR IMAging-study protocol for a randomized diagnostic accuracy trial. [PDF]
Al-Monajjed R +9 more
europepmc +1 more source
Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu +11 more
wiley +1 more source
Data and Safety Monitoring Board Best Practices in Clinical Trials. [PDF]
Klein GL +8 more
europepmc +1 more source
Understanding the functions and operations of data monitoring committees: Survey and focus group findings [PDF]
Karim A. Calis +5 more
openalex +1 more source
Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan +14 more
wiley +1 more source
Can Hironori Sakai be a member of the Independent Data Monitoring Committee?
Toshiya Sato, H. Sakai
openalex +2 more sources
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak +4 more
wiley +1 more source
Effects of modified site for radial artery cannulation on the stability of arterial blood pressure monitoring in patients undergoing elective surgery (MoSRAC): protocol for a randomised controlled trial. [PDF]
Yang X +13 more
europepmc +1 more source
Who's minding the data? Data Monitoring Committees in clinical cancer trials [PDF]
Peter Keating, Alberto Cambrosio
openalex +1 more source

