Results 91 to 100 of about 24,365,275 (295)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A simulation comparison of normalization procedures for TOPSIS

, 2009
Multiattribute decision making (MADM) uses a normalization procedure to transform performance ratings with different data measurement units in a decision matrix into a compatible unit.
Chung-Hsing Yeh, Chakraborty, Subrata, Yeh, Chung-Hsing, Subrata Chakraborty   +3 more
core   +1 more source

Error, reproducibility and sensitivity : a pipeline for data processing of Agilent oligonucleotide expression arrays [PDF]

, 2010
Background Expression microarrays are increasingly used to obtain large scale transcriptomic information on a wide range of biological samples. Nevertheless, there is still much debate on the best ways to process data, to design experiments and analyse ...
Tsang, Jhen, Hammond, J., Bowen, H., Jane Rasaiyaah, Noursadeghi, M., Posch, W., Helen Bowen, Wilfried Posch, Hammond, John, Chain, B., Chain, B. M., Chain, Benjamin, Benjamin Chain, Noursadeghi, Mahdad, Mahdad Noursadeghi, John Hammond, Bowen, Helen C., Rasaiyaah, Jane, Hammond, John P., Rasaiyaah, J., Posch, Wilfried, Tsang, J., Jhen Tsang, Bowen, Helen   +23 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Evaluating the Impact of Data Normalization on Probability Distributions

Applied Sciences
Identification of data distribution and data normalization are fundamental steps in data pre-processing and statistical modeling. Probability distribution identification is essential for selecting an appropriate statistical model, whereas normalization ...
Mannat Mand, Birmohan Singh, Vijay Kumar Kukreja   +2 more
doaj   +1 more source

A nondimensional normalization scheme for oxygen utilization data

, 2006
The total oxygen required for gait (gross utilization) is a widely used indicator of locomotor efficiency. The standard scheme of mass normalization (dividing gross utilization by mass) is intended to eliminate confounding effects that arise from ...
Schwartz, MH, Baker, RJ, Koop, SE, Bourke, JL   +3 more
core   +1 more source

Construction of an adult barnacle (Balanus amphitrite) cDNA library and selection of reference genes for quantitative RT-PCR studies [PDF]

, 2009
De Gregoris TB, Borra M, Biffali E, et al. Construction of an adult barnacle (Balanus amphitrite) cDNA library and selection of reference genes for quantitative RT-PCR studies. BMC Molecular Biology.
De Gregoris, Tristano Bacchetti, Clare, Anthony S., Biffali, Elio, Elio Biffali, Thomas Bekel, Bekel, Thomas, Richard R Kirby, Borra, Marco, J Grant Burgess, Marco Borra, Burgess, J. Grant, Bacchetti De Gregoris, Tristano, Anthony S Clare, Kirby, Richard R., Tristano Bacchetti De Gregoris   +14 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Tail‐Robust Quantile Normalization

, 2020
High-throughput biological data—such as mass spectrometry (MS)-based proteomics data—suffer from systematic non-biological variance due to systematic errors.
Eva Brombacher, Ariane Schad, Schad, Ariane, Clemens Kreutz, Brombacher, Eva, Kreutz, Clemens   +5 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source