Results 121 to 130 of about 361,099 (313)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Workshop on Data Communications
, 1976 With many existing computer networks and many more planned to come into operation, new problems are beginning to appear concerning their inter-connection. On September 15-19.
IIASA Computer Science Project
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Frontiers in PharmacologySynthetic lethality (SL) is widely used to discover the anti-cancer drug targets. However, the identification of SL interactions through wet experiments is costly and inefficient.
Ge Zhang +12 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Processing of experimental data on the computer
, 2018 The manual provides information about the main methods and tools for automation of computational processes used in data processing, methods of presentation and model generation of experimental data, data models and classification of processing tasks, the
Юлия Кухта +9 more
core +1 more source
Multi-Level Intertemporal Attention-Guided Network for Change Detection in Remote Sensing Images
Remote SensingChange detection (CD) is detecting and evaluating surface changes by comparing Remote Sensing Images (RSIs) at different times, which is of great significance for environmental protection and urban planning.
Shuo Liu +5 more
doaj +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Logical timestamps in distributed transaction processing systems
, 2018 Thesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018Cataloged from PDF version of thesis.Includes bibliographical references (pages 73-79).Distributed transactions are such transactions with
Xia, Yu(Scientist in electrical engineering and computer science)Massachusetts Institute of Technology.
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source