Results 141 to 150 of about 361,099 (313)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Application of Machine Learning Techniques to Time-Series Data
, 1995 "Knowledge discovery" is one of the most recent and fastest growing fields of research in computer science. It combines techniques from machine learning and database technology to find and extract meaningful knowledge from large, real world ...
Scott Mitchell, Mitchell, R. Scott
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
An efficient framework for secure dynamic skyline query processing in the cloud
This study introduces an innovative framework named scale for processing dynamic skyline queries securely in cloud environments. Unlike previous approaches that require complex operations on encrypted data, scale simplifies dynamic skyline domination to ...
Xu, Baochao +7 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Data science strategy for injury and violence prevention [PDF]
Injuries and violence are the leading causes of death in the United States for children, adolescents, and adults ages 18 to 44 years and rank in the top 10 causes of death for persons 45 years or older. In recent years, rates of deaths due to many forms
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Research in Computer Science and Computer Engineering
, 2012 This report describes many of the computer related research efforts at the University of Rochester. The Department of Computer Science is involved in research in automatic programming, including very high level languages and data structures; machine ...
Merriam, C. W., Feldman, J. A.
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