Results 161 to 170 of about 361,099 (313)

Computer Vision-Assisted Semiautomatic Analysis of Zooplankton in a Longitudinal Study of the Ecological State of Lake Baikal. [PDF]

open access: yesBiology (Basel)
Rusanovskaya OO   +7 more
europepmc   +1 more source

Using natural language processing to facilitate the harmonization of mental health questionnaires: a validation study using real-world data Lecturer in Psychology Professor of Computer Science Associate professor Pesquisador pós-doutor Newton Fellow

open access: yes
Pooling data from different sources may help further mental health research by providing larger sample sizes and allowing cross-study comparisons; however, the heterogeneity in how variables are measured across studies poses a significant challenge to this process.
Eoin McElroy   +6 more
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Study of IA methods in data analytics (machine learning / deep learning) to improve the content of computer science MOOCs and contribution to the design of the FUN (France Université Numérique) data processing chain

open access: yes
Étude des méthodes IA d'analyse de données (machine learning / deep learning) pour l'amélioration du contenu des MOOCs informatiques et contribution à la conception de la chaîne de traitement des données de FUN (France Université Numérique) Les cours en ligne ouverts et massifs (MOOC), introduits en 2008 et popularisés par des ...
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Graduate application processing system (GAPS)

open access: yes, 1991
The Graduate Application Processing System (GAPS) is a multi-user relational database application which is aimed at computerizing the processing of applications to the graduate programs in the Computer Science Department at California State University ...
Baek, Woon C.
core  

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