Results 51 to 60 of about 1,503,470 (267)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Study on the Corrosion Behavior and Mechanism of Supersonic Flame Sprayed C276 Coating in Simulated Seawater Environment

Metals
In this study, a Hastelloy C276 coating was fabricated on the surface of Q345B steel using high-velocity oxy-fuel (HVOF) spraying technology, and the corrosion behavior and mechanism of the coating in a simulated seawater environment were investigated ...
Long Yan, Ping Liang, Zengyao Chen, Hongchi Ma, Zhong Li, Cuiwei Du, Zhiyong Liu   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Rapid screening of the stability of polyacrylamide-based hydrogel coatings via droplet microarray analysis and interpretable machine learning

npj Materials Degradation
The unsatisfactory stability of hydrogel coatings hinders their functional and service performance. Until now, the development of high-performance hydrogel coatings largely relies on the intuition and prior experience of researchers. Machine learning, as
Jingzhi Yang, Yami Ran, Yuting Jin, Annan Kong, Mingyue Zhang, Lingwei Ma, Dawei Zhang   +6 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Deep learning accelerated the discovery of multi‐principal element alloys with various strength‐toughness trade‐offs

Materials Genome Engineering Advances
Machine learning has significantly enhanced the efficiency of multi‐principal element alloys (MPEAs) development. Nonetheless, despite its potential, the rapid discovery of MPEAs with various strength‐toughness trade‐offs remains a largely unexplored ...
Chunhui Fan, Hong Luo, Qiancheng Zhao, Xuefei Wang, Hongxu Cheng, Yue Chang   +5 more
doaj   +1 more source

GAMMA_FLOW: Guided Analysis of Multi-label spectra by MAtrix Factorization for Lightweight Operational Workflows

SoftwareX
gamma_flow is an open-source Python package for real-time analysis of spectral data. It supports classification, denoising, decomposition, and outlier detection of both single- and multi-component spectra.
Viola Rädle, Tilman Hartwig, Benjamin Oesen, Emily Alice Kröger, Julius Vogt, Eike Gericke, Martin Baron   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source