Results 71 to 80 of about 1,503,470 (267)

Corrosion Behavior of Printed Circuit Boards in Tropical Marine Atmosphere

International Journal of Electrochemical Science, 2019
Outdoor exposure experiments of PCB-Cu, PCB-ImAg and PCB-ENIG were conducted in a tropical marine atmosphere under the synergistic effect of multiple factors, and the corresponding corrosion behavior of the PCBs was investigated by SEM, EDS and EIS.
Yali Feng, Ziheng Bai, Qiong Yao, Dongjiu Zhang, Jialiang Song, Chaofang Dong, Junsheng Wu, Kui Xiao   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effect of Cr on the microstructure and corrosion behavior of nickel-based alloys in hydrochloric acid

Journal of Materials Research and Technology
Nickel-base alloy is a type of metal material with excellent properties and is widely used in many fields. However, in the harsh environment of the acid solution, corrosion causes the reduction of the service life of the alloys, thereby limiting the ...
Dianhui Hou, Hong Luo, Zhimin Pan, Qiancheng Zhao, Hongxu Cheng, Xuefei Wang   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Essential role of Si in enhancing corrosion resistance of high strength low alloy steels in marine environment

Journal of Materials Research and Technology
High strength low alloy steels are extensively applied in marine engineering structures (cross-sea bridge, ocean platform, etc), which are usually subjected to severe corrosion in marine atmosphere.
Jinbin Zhao, Pengxin Wang, Hongchi Ma, Xuequn Cheng, Xiaogang Li   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Analysis of Nuclear Explosion Detection Capability of IMS Hydroacoustic Network

Shock and Vibration
The Comprehensive Nuclear Test Ban Treaty (CTBT) organization has established a hydroacoustic network to ensure the effective detection of nuclear explosions in the vast ocean and in the atmosphere over it in order to effectively guarantee the ...
Yan Wang, Wei Tang, Zhehan Liu, Jian Li, Xiaoming Wang, Shiya Zou   +5 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Data protection officer in public administration [PDF]

Strani pravni život, 2020
The rapid technological development and processing of large amount of personal data have led to the need to control the processing of personal data not only by data protection supervisory authorities but also within the public administration ...
Diligenski Andrej V.
doaj