Results 81 to 90 of about 26,824,643 (287)

Rapid screening of the stability of polyacrylamide-based hydrogel coatings via droplet microarray analysis and interpretable machine learning

npj Materials Degradation
The unsatisfactory stability of hydrogel coatings hinders their functional and service performance. Until now, the development of high-performance hydrogel coatings largely relies on the intuition and prior experience of researchers. Machine learning, as
Jingzhi Yang, Yami Ran, Yuting Jin, Annan Kong, Mingyue Zhang, Lingwei Ma, Dawei Zhang   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Deep learning accelerated the discovery of multi‐principal element alloys with various strength‐toughness trade‐offs

Materials Genome Engineering Advances
Machine learning has significantly enhanced the efficiency of multi‐principal element alloys (MPEAs) development. Nonetheless, despite its potential, the rapid discovery of MPEAs with various strength‐toughness trade‐offs remains a largely unexplored ...
Chunhui Fan, Hong Luo, Qiancheng Zhao, Xuefei Wang, Hongxu Cheng, Yue Chang   +5 more
doaj   +1 more source

GAMMA_FLOW: Guided Analysis of Multi-label spectra by MAtrix Factorization for Lightweight Operational Workflows

SoftwareX
gamma_flow is an open-source Python package for real-time analysis of spectral data. It supports classification, denoising, decomposition, and outlier detection of both single- and multi-component spectra.
Viola Rädle, Tilman Hartwig, Benjamin Oesen, Emily Alice Kröger, Julius Vogt, Eike Gericke, Martin Baron   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Fusion of multi source data for atmospheric corrosion evaluation using sensors and image recognition

npj Materials Degradation
s Detecting corrosion in Q235 steel is crucial for ensuring the safety and maintenance of industrial facilities. In this study, we present a novel approach that combines image recognition techniques with corrosion sensor data to improve both the accuracy
Weitong Wu, Di Xu, Liangan Liu, Bingqin Wang, Xuequn Cheng, Xin Zhang, Xiaogang Li   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Inhibitor_Mol_VAE: a variational autoencoder approach for generating corrosion inhibitor molecules

npj Materials Degradation
Deep learning-based generative modeling demonstrates proven advantages as an effective approach in molecular discovery. This study introduces a generative-network based method called Inhibitor_Mol_VAE, which uses a variational autoencoder model to ...
Haiyan Gong, Zhongheng Fu, Lingwei Ma, Dawei Zhang   +3 more
doaj   +1 more source