Results 111 to 120 of about 11,695,622 (343)

Water Resources Data for California, 1965; Part 2: Water Quality Records [PDF]

, 1965

openalex   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Calculating the similarity between prescriptions to find their new indications based on graph neural network

Chinese Medicine
Background Drug repositioning has the potential to reduce costs and accelerate the rate of drug development, with highly promising applications. Currently, the development of artificial intelligence has provided the field with fast and efficient ...
Xingxing Han, Xiaoxia Xie, Ranran Zhao, Yu Li, Pengzhen Ma, Huan Li, Fengming Chen, Yufeng Zhao, Zhishu Tang   +8 more
doaj   +1 more source

Water Resources Data for Colorado, 1966; Part 2. Water Quality Records [PDF]

, 1967

openalex   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Regulatory landscape with U.S. patient requirements and Clinical Trial Diversity expectations

Contemporary Clinical Trials Communications
The Food and Drug Administration (FDA) has an expectation that products filed for marketing authorization have to include data that are representative of the US patient population.
Elizabeth George, Alicia Baker McDowell, Melissa Vozza, Talley Mitchell, Ben Quartley, Cassandra S. Kennedy, Bill Hanlon   +6 more
doaj   +1 more source

Water Resources Data for California, 1967; Part 2: Water Quality Records [PDF]

, 1968

openalex   +1 more source

Guide to Data Quality

, 2017
A successful data analytics project requires a clean sample of data that is representative of the population of interest. The data typically comes from integrating a number of data sources, and the resulting dataset is rarely clean. This document discusses data quality issues that commonly arise in such as dataset, with examples from data typical of ...
openaire   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Classification of data collection methods (= Deliverable 3.1 of the OrganicDataNetwork project - Report on collection methods) [PDF]

, 2013
In this report, a number of evaluation and quality criteria for data collection and compilation methods were defined. The results of an online survey on all existing organic market data collection methods in Europe were compiled and assessed ...
Feldmann , Corinna, Hamm, Ulrich
core