Results 111 to 120 of about 5,645,319 (318)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Modeling Data Quality with Possibility-Distributions

, 2007
Die Beschreibung von Datenqualität basiert vorwiegend auf Zahlenangaben. Beim Arbeiten mit Da-tensätzen, die über einen längeren Zeitraum erfasst wurden, erkennt man schnell Unterschiede in der Qualität verschiedener Daten desselben Datensatzes.
Navratil, Gerhard
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A Quantitative Study Exploring and Comparing Key Factors in Medication Management in the Irish Healthcare Setting

Health Expectations
Background Shared decision‐making in the context of medication management has been shown to be contingent on information‐seeking behaviours such as patient knowledge, self‐efficacy and engagement.
Bernadine O'Donovan, Ciara Kirke, Muriel Pate, Sheena McHugh, Kathleen Bennett, Caitríona Cahir   +5 more
doaj   +1 more source

Comparative effects of behaviour change techniques using eHealth and mHealth in promoting dietary behaviour: protocol for a systematic review and component network meta-analysis

BMJ Open
Introduction Globally, it is estimated that dietary habits contribute to 22% of adult deaths and 15% of disability-adjusted life years, highlighting the critical role of dietary behaviour in public health.
Hisashi Noma, Takahiro Mihara, Takafumi Fukuda, Nozomi Matsuura   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Assessing the Quality of Data with a Decision Model

, 2007
The quality of GIS data cannot be assessed independently of what it should be used for ("fitness for use"); this assessment requires currently human expert interaction.
Frank, Andrew U.
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Data Policies, Data Management and the Quality of Academic Writing

The quality of methodology sections is the result of interaction between academic cultures of data sharing, effective application of rules, academic excellence and good quality Research Data Management (RDM).This data set is based on the coding of 66 ...
Jensen, Uwe, GESIS - Leibniz Institute for the Social Sciences, Horton, Laurence, London School of Economics and Political Science, Katsanidou, Alexia, GESIS - Leibniz Institute for the Social Sciences   +2 more
core   +1 more source