Results 91 to 100 of about 13,470,212 (338)

Intersections between Information Science and Big Data

open access: yesEm Questão
The aim of this work is to identify the interrelationships between Big Data and Information Science based on a literature review of scientific communications indexed in the Scopus and Web of Science databases ...
Joel Perozo-Vasquez   +2 more
doaj   +1 more source

Political Science Is a Data Science

open access: yesThe Journal of Politics, 2021
This discussion is about changes in the world, changes that affect us as academics, changes that affect us as empirical researchers (qualitative and quantitative), and changes that affect our students and our universities/ colleges I am an empirical social scientist, a political methodologist, and a statistician, so I will only discuss topics along ...
openaire   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

open access: yesFEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman   +3 more
wiley   +1 more source

Enabling data‐driven collaborative and reproducible environmental synthesis science

open access: yesMethods in Ecology and Evolution
This manuscript shares the lessons learned from providing scientific computing support to over 600 researchers and discipline experts, helping them develop reproducible and scalable analytical workflows to process large amounts of heterogeneous data ...
Julien Brun   +7 more
doaj   +1 more source

Informaticology: combining Computer Science, Data Science, and Fiction Science

open access: yes, 2012
Motivated by an intention to remedy current complications with Dutch terminology concerning informatics, the term informaticology is positioned to denote an academic counterpart of informatics where informatics is conceived of as a container for a ...
Bergstra, Jan A.
core  

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Improving Earth Science Data Literacy [PDF]

open access: yes
The improvement of scientific literacy across the public can take on a myriad of forms and activities. The vast archives of NASAs Earth science data, as one example, reflect the agencys ongoing commitment to producing the highest quality data, services ...
Behnke, Jeanne   +2 more
core   +1 more source

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