Results 91 to 100 of about 53,144,553 (313)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Responsible Data Science [PDF]

Proceedings of the 2019 International Conference on Management of Data, 2019
Data science is an emerging discipline that offers both promise and peril. Responsible data science refers to efforts that address both the technical and societal issues in emerging data-driven technologies. How can machine learning and database systems reason effectively about complex dependencies and uncertainty? Furthermore, how do we understand the
openaire   +1 more source

Bringing Interdisciplinary Data Science Education Challenges into the Classroom

Journal of Statistics and Data Science Education
This article examines the growing prevalence and challenges of interdisciplinary data science education (IDSE) in higher education globally. We argue that while data science education has traditionally focused on statistical and computational skills ...
Zofia Bednarowska-Michaiel, Emma Uprichard   +1 more
doaj   +1 more source

Data Wealth, Data Poverty, Science and Cyberinfrastructure

Prometheus, 2008
Changes in access to data are leading to rapid ‘data wealth’ in some scientific fields, even as others remain ‘data‐poor’. Furthermore, the current attention towards developing computer‐based infrastructures and digital access to common data sets—the ...
Steve Sawyer
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

A Systematic Literature Review of Undergraduate Data Science Education Research

Journal of Statistics and Data Science Education
The presence of data science has been profound in the scientific community in almost every discipline. An important part of the data science education expansion has been at the undergraduate level.
Mine Dogucu, Sinem Demirci, Harry Bendekgey, Federica Zoe Ricci, Catalina M. Medina   +4 more
doaj   +1 more source

Shared data science infrastructure for genomics data

BMC Bioinformatics, 2019
Background Creating a scalable computational infrastructure to analyze the wealth of information contained in data repositories is difficult due to significant barriers in organizing, extracting and analyzing relevant data.
Hamid Bagheri, Usha Muppirala, Rick E. Masonbrink, Andrew J. Severin, Hridesh Rajan   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Data, Science and Society

CoRR, 2017
Notes for a talk at LEARN Final Conference, Economic Commission for Latin America and the Caribbean (ECLAC), Senate House, University of London, London, May 5th ...
openaire   +2 more sources